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Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
150 mg/kg bw/day
Study duration:

Additional information

Oxalates can be assimilated to oxalic acid. Two repeated dose studies were conducted, which are summarized in the following table.

Study references

Study type




NON KEY_1977_lit_Goldman

Oral via food (2,5 and 5%), 70 days, effects on growth and reproduction

Decrease in growth rate, body weight, reproductive tissue weights

No NOAEL identified


NON KEY_1979_lit_Goldman

Oral via food (2,5 and 5%), 70 days, effects on thyroid function

Decreased body and thyroid weight at 2.5 and 5%, state of thyroidism at 5%

No NOAEL identified


Both works of Goldman, M et al. studying the sub-chronic toxicity with repeated doses in rats for 70 days are considered by the Agencies (EU: EMEA & PAN Pesticides Database-Chemicals, U.S. National Toxicology Program) as the basis of repeated dose toxicity 2000 mg / kg bw / day. The Japanese Agency (NITE, National Institute of Technology and Evaluation) provides a GLP work, OECD 407 in rats in repeated doses for 28 days, which showed no change in weight or quantity of water or food consumed, or biochemical changes were observed or in urine, no significant change in weight of organs in both sexes. But in high doses, 150 mg/kg bw and 400 mg / kg bw significant histopathological changes were observed in the gastric mucosa; that established a LOAEL of 150 mg/kg/d bw, since no lower doses were tested.

In assessing the hazard of oxalic acid, it should be kept in mind that oxalic acid is a natural substance which is present in various food substances, and in this way is consumed by the general population daily. From Gold et al (2001), the following table was derived, in which the average daily consumption of oxalic acid containing food is summarized. A total average daily consumption of 68.4 mg oxalic acid can be calculated from this table.

Food substance (average daily consumption)

Average daily oxalic acid consumption

Coffee (500 mL)

25.2 mg

Carrot (boiled, 12.1 g)

22.7 mg

Tea (60.2 mL)

6.67 mg

Chocolate (cocoa solids, 3.34 g)

3.91 mg

Tomato (88.7 g)

3.24 mg

Celery (7.95 g)

1.39 mg

Potato (54.9 g)

1.26 mg

Corn (33.8 g)

1.12 mg

Apple (32.0 g)

704 µg

(10.5 g)

651 µg

Lettuce (14.9 g)

447 µg

Broccoli (6.71 g)

268 µg

Strawberry (4.38 g)

261 µg

Cabbage (boiled, 12.9 g)

155 µg

Grapes (11 g)

138 µg

Cucumber (raw flesh, 11.8 g)

118 µg

Peach (canned, 9.58 g)

115 µg

Onions (green, cooked, 137 mg)

31.5 µg

Justification for classification or non-classification

Data do not support classification.