Registration Dossier
Registration Dossier
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EC number: 204-873-0 | CAS number: 127-95-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Oxalic acid
- EC Number:
- 205-634-3
- EC Name:
- Oxalic acid
- Cas Number:
- 144-62-7
- IUPAC Name:
- oxalic acid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- dimethyl sulphoxide
- Concentration:
- 12.5%, 25% and 50%
- No. of animals per dose:
- 3 test groups of 5 animal (3 different concentrations).
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: see Remark
- Remarks:
- None of the 3 concentrations tested reached the stimulation index of 3: The stimulation index at a concentration of 12.5% was of 2.6 The stimulation index at a concentration of 25% was of 1.9 The stimulation index at a concentration of 50% was of 2.5
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- The EC3 value (derived by linear interpolation) could not be calculated as the
stimulation indices of all concentrations were below 3.
Consequently, according to OECD 429 and the criteria given in Annex I of Regulation (EC) 1272/2008, the test item Oxalic Acid, as described in this report is expected to have no sensitising properties and therefore, should not be regarded as a dermal sensitiser
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