Potassium hydrogen oxalate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

no data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: scientifically acceptable.

Data source

Reference

Reference Type:

publication

Title:

Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions

Author:

Vernot, E.H., MacEwen, J.D., Haun, C.C., Kinkead, E.R.

Year:

1977

Bibliographic source:

Toxicology and Applied Pharmacology, Vol 42, p 417-423

Materials and methods

Test guideline

Qualifier:

no guideline followed

Guideline:

other: according to the method of Smyth et al. (1962)

Principles of method if other than guideline:

Single oral dose toxicity determined by the method of Smyth et al. (1962), no details on method provided.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Oxalic acid

EC Number:

205-634-3

EC Name:

Oxalic acid

Cas Number:

144-62-7

IUPAC Name:

oxalic acid

Details on test material:

5% aqueous solution

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

water

Doses:

no data

No. of animals per sex per dose:

no data

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

9.5 mL/kg bw

95% CL:

5.4 - 12.3

Remarks on result:

other: (475 mg/kg bw)

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

7.5 mL/kg bw

95% CL:

5 - 11

Remarks on result:

other: (375 mg/kg bw)

Any other information on results incl. tables

The following table is reproduced from the publication. Only the relevant part concerning oxalic acid is reproduced.

Material studied	Single oral LD50
	Male rats	Other
Oxalic acid (5%)	9.5 (5.4-12.3) [mL/kg]	7.5 (5.0-11.0) [mL/kg] (females)

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

In a single oral toxicity test with a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg (475 mg/kg bw) was determined in male rats, and an LD50 of 7.5 mL/kg (375 mg/kg bw) was determined in female rats, under the current test conditions.

Executive summary:

In this study, the single oral dose toxicity of 110 organic and inorganic compounds, including oxalic acid, was tested. For a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg was determined in male rats, and an LD50 of 7.5 mL/kg was determined in female rats, under the current test conditions.