Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Remarks:
other: In vitro
Type of information:
other: in vitro
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: OECD Guideline GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 460: Guideline for testing of chemicals
Principles of method if other than guideline:
Fluorescin leakage test method for identifiying corrosive and severe irritants
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium hydrogen oxalate
EC Number:
204-873-0
EC Name:
Potassium hydrogen oxalate
Cas Number:
127-95-7
Molecular formula:
C2H2O4.K
IUPAC Name:
potassium hydrogen oxalate

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: in vitro
Time point:
other: other
Score:
< 20
Irritant / corrosive response data:
The substance "potassium trihydrogen dioxalate" on the basis of the negative results cannot be classified as GHS cat1 in the experimental conditions performed. For this reason, it should be tested witha another validated in vitro or ex vivo ocular or skin protocol to assesss its eye irritation/corrosion potential following the sequential testing strategy for the acute eye irritation ab¡nd corrosion, outlined in the OECD TG 405 and EU Test Method B.5 (OECD, 21012; EU TRM B.5, 2008)

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
The substance "potassium trihydrogen dioxalate" on the basis of the negative results cannot be classified as GHS cat1 in the experimental conditions performed. For this reason, it should be tested witha another validated in vitro or ex vivo ocular or skin protocol to assesss its eye irritation/corrosion potential following the sequential testing strategy for the acute eye irritation ab¡nd corrosion, outlined in the OECD TG 405 and EU Test Method B.5 (OECD, 21012; EU TRM B.5, 2008)