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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
January 1986 - July 1987
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study is not according to an international accepted guideline, nor is any data available on GLP. The study is described in a publication which provides very limited information on used methods, performance and raw data.

Data source

Reference
Reference Type:
publication
Title:
Fussruckenekzeme infolge von Ledersensibilirierung
Author:
Gehring, W., Gloor, M., Gehse, M.
Year:
1988
Bibliographic source:
Fortschr. Med. Vol 106 Nr 3 pp 45 - 46

Materials and methods

Type of sensitisation studied:
skin
Study type:
not specified
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
26 patients with sympthoms of eczema on the dorsum of the foot were tested for sensitizing responses after application of several substances used in the manufacture of leather (tanning and dyeing agents), including oxalic acid. No details on the used method were included in the report
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Oxalic acid
EC Number:
205-634-3
EC Name:
Oxalic acid
Cas Number:
144-62-7
IUPAC Name:
oxalic acid
Details on test material:
- Name of test material (as cited in study report): Oxalsäure
- Physical state: liquid (solution in water)

Method

Type of population:
general
Controls:
No data
Route of administration:
dermal

Results and discussion

Results of examinations:
SYMPTOMS
- Frequency, level, duration of symptoms observed:
No data


NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 14 (n = 26)
- Number of subjects with negative reactions no data
- Number of subjects with equivocal reactions no data
- Number of subjects with irritating reactions no data


RESULT OF CASE REPORT:
no data

OTHER RESULTS:
no data

Applicant's summary and conclusion

Conclusions:
Under the conditions of the test oxalic acid is found to be a relevant allergen.
Executive summary:

In skin testing of patients with eczema of the dorsum of the foot, allergens used in the manufacture of leather as tanning and dyeing agents, were applied. It was seen that potassium dichromate has no particular significance. Oxalic acid and phenylhydrazine, present in traces in leather dyes, as also dinitrochlorbenzene are all equally potent sensitizing agents.

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