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Diss Factsheets
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EC number: 204-873-0 | CAS number: 127-95-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- January 1986 - July 1987
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study is not according to an international accepted guideline, nor is any data available on GLP. The study is described in a publication which provides very limited information on used methods, performance and raw data.
Data source
Reference
- Reference Type:
- publication
- Title:
- Fussruckenekzeme infolge von Ledersensibilirierung
- Author:
- Gehring, W., Gloor, M., Gehse, M.
- Year:
- 1 988
- Bibliographic source:
- Fortschr. Med. Vol 106 Nr 3 pp 45 - 46
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- not specified
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 26 patients with sympthoms of eczema on the dorsum of the foot were tested for sensitizing responses after application of several substances used in the manufacture of leather (tanning and dyeing agents), including oxalic acid. No details on the used method were included in the report
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Oxalic acid
- EC Number:
- 205-634-3
- EC Name:
- Oxalic acid
- Cas Number:
- 144-62-7
- IUPAC Name:
- oxalic acid
- Details on test material:
- - Name of test material (as cited in study report): Oxalsäure
- Physical state: liquid (solution in water)
Constituent 1
Method
- Type of population:
- general
- Controls:
- No data
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed:
No data
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 14 (n = 26)
- Number of subjects with negative reactions no data
- Number of subjects with equivocal reactions no data
- Number of subjects with irritating reactions no data
RESULT OF CASE REPORT:
no data
OTHER RESULTS:
no data
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the test oxalic acid is found to be a relevant allergen.
- Executive summary:
In skin testing of patients with eczema of the dorsum of the foot, allergens used in the manufacture of leather as tanning and dyeing agents, were applied. It was seen that potassium dichromate has no particular significance. Oxalic acid and phenylhydrazine, present in traces in leather dyes, as also dinitrochlorbenzene are all equally potent sensitizing agents.
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