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Diss Factsheets
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EC number: 204-873-0 | CAS number: 127-95-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not performed according to a guideline, but materials & methods and results are well described. Only absorption/excretion is studied.
Data source
Reference
- Reference Type:
- publication
- Title:
- Absorption of oxalic acid in rats by means of a 14C method
- Author:
- Bannwart, C., Hagmaier, V., Rutishauser
- Year:
- 1 979
- Bibliographic source:
- European Urology, Vol 5, p 276-277
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 13 female Wistar rats received a daily dose of 0.5 mL of a 1% solution of 14C-marked sodium oxalate (specific activity 29 nCi/mL) by gavage. This concentration corresponds to 17 mg oxalic acid/kg/day, which lies between the values found for humans 1-14 mg/kg/day) and rats (46-92 mg/kg/day). Feces and urine were collected every 24 hr and the amount of 14C-oxalate was determined by liquid scintillation counting.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Oxalic acid
- EC Number:
- 205-634-3
- EC Name:
- Oxalic acid
- Cas Number:
- 144-62-7
- IUPAC Name:
- oxalic acid
- Details on test material:
- Specific activity of the 14C-marked oxalate solution was 29 nCi/mL
Sodium oxalate was obtained from Merck, 14C-oxalate, H2C2O4 double brand was obtained from Amersham
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 g
- Individual metabolism cages: yes
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
TEST SUBSTANCE
-Specific activity of 14C-marked solution: 29 nCi/mL
VEHICLE
- Concentration in vehicle: 1% sodium oxalate solution
- Amount of vehicle (if gavage): 0.5 mL - Duration and frequency of treatment / exposure:
- Animals were treated once daily, over a 7-day period
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5 mL of a 1% sodium oxalate solution
- No. of animals per sex per dose / concentration:
- One dose tested, 13 animals
- Control animals:
- no
- Positive control reference chemical:
- No data
- Details on study design:
- No data
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: urine, faeces
- Time and frequency of sampling: daily (before the administration of every new dose of oxalate solution) - Statistics:
- No data
Results and discussion
- Preliminary studies:
- Not applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The distribution of 14C-oxalate in the excretion of 13 animals during a 7-day period is 25.2% in urine and 73.4% in feces. The over-all recovery is 98.6%.
- Details on distribution in tissues:
- No data
Transfer into organs
- Observation:
- not determined
- Details on excretion:
- The distribution of 14C-oxalate in the excretion of 13 animals during a 7-day period is 25.2% in urine and 73.4% in feces. The over-all recovery is 98.6%.
Metabolite characterisation studies
- Metabolites identified:
- not specified
Any other information on results incl. tables
The following table is reproduced from the publication. It summarizes the distribution of 14C-oxalate between faeces and urine in 13 animals for 7 days (1 daily dose = 100%)
Animal no. |
Feces, % |
Urine, % |
1 |
73.5 |
14.0 |
2 |
50.7 |
33.1 |
3 |
74.2 |
42.0 |
4 |
58.2 |
31.9 |
5 |
67.8 |
22.9 |
6 |
65.0 |
33.2 |
7 |
84.9 |
20.1 |
8 |
67.2 |
26.6 |
9 |
80.1 |
27.8 |
10 |
80.5 |
20.9 |
11 |
99.5 |
18.5 |
12 |
72.4 |
30.3 |
13 |
79.5 |
15.6 |
_ x |
73.4 |
25.2 |
Total |
98.6% |
|
s |
12.4 |
6.9 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Under the conditions of the current study, the distribution of 14C-oxalate in the excretion of 13 animals during a 7-day period is 25.2% in urine and 73.4% in feces. The over-all recovery was 98.6%. - Executive summary:
13 female Wistar rats received a daily dose of 0.5 mL of a 1% solution of 14C-marked sodium oxalate (specific activity 29 nCi/mL) by gavage. This concentration corresponds to 17 mg oxalic acid/kg/day, which lies between the values found for humans 1-14 mg/kg/day) and rats (46-92 mg/kg/day). Feces and urine were collected every 24 hr and the amount of 14C-oxalate was determined by liquid scintillation counting.
The distribution of 14C-oxalate in the excretion was 25.2% in urine and 73.4% in feces. The over-all recovery was 98.6%.
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