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EC number: 204-633-5 | CAS number: 123-51-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Cardiovascular effects of ethanol, its cogeners and synthetic bourbon in dogs
- Author:
- Nakano J and Kessinger JM
- Year:
- 1 972
- Bibliographic source:
- European Journal of Pharmacology, 17, 195-201
- Reference Type:
- publication
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 009
- Bibliographic source:
- RIFM database
Materials and methods
- Principles of method if other than guideline:
- acc. to Nakano (1964, 1967)
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 3-methylbutan-1-ol
- EC Number:
- 204-633-5
- EC Name:
- 3-methylbutan-1-ol
- Cas Number:
- 123-51-3
- Molecular formula:
- C5H12O
- IUPAC Name:
- 3-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): iso-amyl alcohol
- Source: Fisher Sci. Co., Houston, Texas
Constituent 1
Test animals
- Species:
- dog
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 15 - 30 kg
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- 20 mg/kg bw
- No. of animals per sex per dose:
- 18 animals
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 20 mg/kg bw
- Mortality:
- All dogs expired prior to 1 hour of infusion
- Clinical signs:
- Heart rate, systemic arterial pressure and myocardial contactile force decreased. Pulmonary arterial pressure increased.
Any other information on results incl. tables
The continuous i.v. infusion of iso-amyl alcohol, 20 mg/kg per min, decreased heart rate, systemic arterial pressure and myocardial contractile force progressively and markedly even when the blood iso-amyl alcohol levels were less than 0.2 mg/ml. With the dose of iso-amyl alcohol infusion, all dogs expired prior to 1 hr infusion. In spite of the marked myocardial depression, mean pulmonary arterial pressure increased slightly.
Applicant's summary and conclusion
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