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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Cardiovascular effects of ethanol, its cogeners and synthetic bourbon in dogs
Author:
Nakano J and Kessinger JM
Year:
1972
Bibliographic source:
European Journal of Pharmacology, 17, 195-201
Reference Type:
publication
Title:
No information
Author:
RIFM
Year:
2009
Bibliographic source:
RIFM database

Materials and methods

Principles of method if other than guideline:
acc. to Nakano (1964, 1967)
GLP compliance:
no
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): iso-amyl alcohol
- Source: Fisher Sci. Co., Houston, Texas

Test animals

Species:
dog
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 15 - 30 kg

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Doses:
20 mg/kg bw
No. of animals per sex per dose:
18 animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD100
Effect level:
20 mg/kg bw
Mortality:
All dogs expired prior to 1 hour of infusion
Clinical signs:
Heart rate, systemic arterial pressure and myocardial contactile force decreased. Pulmonary arterial pressure increased.

Any other information on results incl. tables

The continuous i.v. infusion of iso-amyl alcohol, 20 mg/kg per min, decreased heart rate, systemic arterial pressure and myocardial contractile force progressively and markedly even when the blood iso-amyl alcohol levels were less than 0.2 mg/ml. With the dose of iso-amyl alcohol infusion, all dogs expired prior to 1 hr infusion. In spite of the marked myocardial depression, mean pulmonary arterial pressure increased slightly.

Applicant's summary and conclusion