Registration Dossier
Registration Dossier
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EC number: 204-633-5 | CAS number: 123-51-3
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity
Short-term toxicity to fish
The acute toxicity of the test substance 3-methylbutan-1-ol to Salmo gairdneri (new name: Oncorhynchus mykiss) was assessed according to OECD 203 under static conditions (Hoechst AG, 1979). The 96 hour LC50 was determined to be nominal 700 mg/L. In addition study data of other category members are available all revealing LC50 values well above 100 mg/L.
Long-term toxicity to fish
Experimental study planned
Data for long-term toxicity to fish will be available in 2023 for an analogue approach (Pentan-1-ol, CAS 71-41-0) and are considered to be used to cover this endpoint. Due to animal welfare reasons, we suggest to use analogue date when available.
Short-term toxicity to aquatic invertebrates
The acute toxicity of the surrogate test substance to Daphnia magna was assessed according to DIN 38412 L11 (BASF 1990). The 48 h-EC50 value was determined to be nominal 255 mg test item/L. In addition study results are available for all the other category members, all revealing EC50 values well above 100 mg/L.
Long-term toxicity to aquatic invertebrates
Experimental study planned
Data for long-term toxicity to aquatic invertebrates will be available in 2023 for an analogue approach (Pentan-1-ol, CAS 71-41-0) and are considered to be used to cover this endpoint. We suggest to use analogue date when available.
Toxicity to algae and cyanobacteria
The toxicity of the test substance on Scenedesmus subspicatus (new name: Desmodesmus subspicatus) was determined according to DIN 38412 part 9 under Non-GLP conditions (BASF 1989). After 72 hours the ErC10 was determined to be 141 mg/L and the EC50 was determined to be greater than 500 mg/L (growth rate) and 493 mg/L (biomass). All values based on nominal concentrations. In addition study results are available for the other category members, revealing EC50 and EC10 values well above 100 mg/L.
Toxicity to aquatic plants other than algae
Data on toxictiy to aquatic plant other than algae are not required for REACh registration.
Toxicity to microorganisms
The toxic effects of the surrogate test substances pentanol, branched and linear (CAS 94624-12-1) and 2-methylbutan-1-ol were determined based on the oxygen consumption rate of aerobic micro-organisms (activated sludge) after short-term exposure of 180 min according to the OECD test guideline 209. Read across was applied using these results and the EC50 of the test substance was determined to be greater than 1000 mg/L and the EC10 was determined to be 370 mg/L.
Toxicity to other aquatic organisms
No requirement under REACh
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