Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

 

 

Aquatic toxicity

Short-term toxicity to fish

The acute toxicity of the test substance 3-methylbutan-1-ol to Salmo gairdneri (new name: Oncorhynchus mykiss) was assessed according to OECD 203 under static conditions (Hoechst AG, 1979). The 96 hour LC50 was determined to be nominal 700 mg/L. In addition study data of other category members are available all revealing LC50 values well above 100 mg/L.

 

Long-term toxicity to fish

In Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Regulation (EC) No 1272/2008 (CLP Regulation) orD irective 67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB. The hazard assessment of 3-methylbutan-1-ol reveals neither a need to classify the substance as dangerous for the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore, and for reasons of animal welfare, a long-term toxicity study in fish is not provided.

 

Short-term toxicity to aquatic invertebrates

The acute toxicity of the surrogate test substance to Daphnia magna was assessed according to DIN 38412 L11 (BASF 1990). The 48 h-EC50 value was determined to be nominal 255 mg test item/L. In addition study results are available for all the other category members, all revealing EC50 values well above 100 mg/L.

 

Long-term toxicity to aquatic invertebrates

In Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms.

According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the crit eria for classification as dangerous according to Regulation (EC) No 1272/2008 (CLP Regulation) or Directive 67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB.

The hazard assessment of 3-methylbutan-1-ol reveals neither a need to classify the substance as dangerous for the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore a long-term toxicity study in aquatic invertebrates is not provided.

 

Toxicity to algae and cyanobacteria

The toxicity of the test substance on Scenedesmus subspicatus (new name: Desmodesmus subspicatus) was determined according to DIN 38412 part 9 under Non-GLP conditions (BASF 1989). After 72 hours the ErC10 was determined to be 141 mg/L and the EC50 was determined to be greater than 500 mg/L (growth rate) and 493 mg/L (biomass). All values based on nominal concentrations. In addition study results are available for the other category members, revealing EC50 and EC10 values well above 100 mg/L.

 

Toxicity to aquatic plants other than algae

Data on toxictiy to aquatic plant other than algae are not required for REACh registration.

 

Toxicity to microorganisms

The toxic effects of the surrogate test substances pentanol, branched and linear (CAS 94624-12-1) and 2-methylbutan-1-ol were determined based on the oxygen consumption rate of aerobic micro-organisms (activated sludge) after short-term exposure of 180 min according to the OECD test guideline 209. Read across was applied using these results and the EC50 of the test substance was determined to be greater than 1000 mg/L and the EC10 was determined to be 370 mg/L.

  

Toxicity to other aquatic organisms

No requirement under REACh