Registration Dossier
Registration Dossier
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EC number: 204-633-5 | CAS number: 123-51-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII
- Author:
- Smyth HF et al.
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. J. 30, 470-476
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs - Isoamly alcohol
- Author:
- Opdyke DLJ
- Year:
- 1 978
- Bibliographic source:
- Food Chem. Tox. 16, S1, 785-788
- Reference Type:
- secondary source
- Title:
- RIFM database
- Author:
- RIFM
- Year:
- 2 009
Materials and methods
- Principles of method if other than guideline:
- acc. Carpenter CP und Smyth Jr. HF, Am. J. Ophthal., 29, 1363, 1946
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-methylbutan-1-ol
- EC Number:
- 204-633-5
- EC Name:
- 3-methylbutan-1-ol
- Cas Number:
- 123-51-3
- Molecular formula:
- C5H12O
- IUPAC Name:
- 3-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 3-methyl-1-butanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- other: undiluted or as a solution in propylene glycol and water
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.005 - 0.5 ml
- Concentration (if solution): 1% - 100% - Duration of treatment / exposure:
- one application, no washing
- Observation period (in vivo):
- 24 h
- Number of animals or in vitro replicates:
- 5/dose
- Details on study design:
- SCORING SYSTEM:
Grading according to a 10-grade series:
grade 1 = indicates at most a very small area of necrosis from 0.5 ml of undiluted test material;
grade 5 = indicates a so-called severe burn from 0.005 ml of undiluted test material;
10 = a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Grading
- Basis:
- other: no specified
- Time point:
- other: 24 h
- Score:
- 8
- Max. score:
- 10
- Reversibility:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
