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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was conducted prior to GLP as well as Guidelines but some information regarding standard test procedure was documented. For justification of read-across please refer to section 13.
Justification for type of information:
A read-across justification is provided in the IUCLID Chapter "Assessment reports"

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No guideline available in the report.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No additional information available.

Test animals / tissue source

Species:
rabbit
Strain:
other: albino

Test system

Vehicle:
other: undiluted or 5 or 15% dilution in propylene glycol
Controls:
not specified
Amount / concentration applied:
Five rabbits were dosed in one eye with 0.005 ml of undiluted material.
Four rabbits were dosed in one eye with 0.5 ml of a 15% dilution in propylene glycol.
Additional eyes, number unstated, were dosed with 0.5 ml of a 5% dilution in propylene glycol.
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
Eyes are scored immediately unstained and after 24 hours following fluorescein administration.
Number of animals or in vitro replicates:
Various, see above.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other:
Remarks on result:
other: 0.005 mL of the undiluted substance resulted in moderate to severe injury with iritis in 2 of 5 eyes.
Irritation parameter:
other:
Remarks on result:
other: 0.5 mL of a 15 % dilution resulted in severe corneal injury with iritis in 2 of 4 eyes.
Irritation parameter:
other:
Remarks on result:
other: 0.5 mL of a 5 % dilution resulted in no corneal injury.
Irritant / corrosive response data:
Undiluted material - 0.005 ml resulted in moderate to severe corneal injury with iritis in 2 of 5 eyes.

15% dilution - 0.5 ml resulted in severe corneal injury with iritis in 2 of 4 eyes.

5% dilution - 0.5 ml resulted in no corneal injury.
Other effects:
Undiluted material - 0.005 ml resulted in moderate to severe corneal injury with iritis in 2 of 5 eyes.

15% dilution - 0.5 ml resulted in severe corneal injury with iritis in 2 of 4 eyes.

5% dilution - 0.5 ml resulted in no corneal injury.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Conclusions:
Instillation of the undiluted or diluted material resulted in moderate to severe corneal injury, with iritis, in rabbit eyes.
Executive summary:

The eye irritation potential of n-pentanol was examined. Instillation of the undiluted or diluted material resulted in moderate to severe corneal injury, with iritis, in rabbit eyes.