Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only abstract available

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fatal poisoning with sythetic isoamyl alcohol
Author:
Avdeev YI
Year:
1966
Bibliographic source:
Nauch. Tr. Omsk. Med. Inst., 69, 146
Reference Type:
secondary source
Title:
Fragrance raw materials monographs: isoamyl alcohol
Author:
Opdyke DLJ
Year:
1978
Bibliographic source:
Food Cosmet. Toxicol., 16,785-788
Reference Type:
secondary source
Title:
No information
Author:
BG Chemie
Year:
2002
Bibliographic source:
BG Datenkataolg Nr. 95: 3-Methylbutanol-1

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: oral
Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): isoamyl alcohol

Method

Type of population:
not specified
Subjects:
no data
Route of exposure:
oral
Reason of exposure:
accidental
Exposure assessment:
not specified
Details on exposure:
Ingestion of 50 - 100 ml isoamyl alcohol

Results and discussion

Clinical signs:
Central nervous system depression, weakness, pain, a burning sensation in the chest and stomach, nausea, headache, sleep within 10-15 min, terminal coma and death within 1 hr to 6 days. The cause of death was asphyxiation, and turgor of brain tissues and all internal organs, swollen gastric mucosa and vascular effects were noted .

Applicant's summary and conclusion