Registration Dossier
Registration Dossier
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EC number: 204-633-5 | CAS number: 123-51-3
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fatal poisoning with sythetic isoamyl alcohol
- Author:
- Avdeev YI
- Year:
- 1 966
- Bibliographic source:
- Nauch. Tr. Omsk. Med. Inst., 69, 146
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs: isoamyl alcohol
- Author:
- Opdyke DLJ
- Year:
- 1 978
- Bibliographic source:
- Food Cosmet. Toxicol., 16,785-788
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- BG Chemie
- Year:
- 2 002
- Bibliographic source:
- BG Datenkataolg Nr. 95: 3-Methylbutanol-1
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-methylbutan-1-ol
- EC Number:
- 204-633-5
- EC Name:
- 3-methylbutan-1-ol
- Cas Number:
- 123-51-3
- Molecular formula:
- C5H12O
- IUPAC Name:
- 3-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): isoamyl alcohol
Constituent 1
Method
- Type of population:
- not specified
- Subjects:
- no data
- Route of exposure:
- oral
- Reason of exposure:
- accidental
- Exposure assessment:
- not specified
- Details on exposure:
- Ingestion of 50 - 100 ml isoamyl alcohol
Results and discussion
- Clinical signs:
- Central nervous system depression, weakness, pain, a burning sensation in the chest and stomach, nausea, headache, sleep within 10-15 min, terminal coma and death within 1 hr to 6 days. The cause of death was asphyxiation, and turgor of brain tissues and all internal organs, swollen gastric mucosa and vascular effects were noted .
Applicant's summary and conclusion
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