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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Narcotic and Toxic Potency of Aliphatic Alcohols upon Rabbits
Author:
Munch JC and Schwartze EW
Year:
1925
Bibliographic source:
J. Lab. Clin. Med., 10:985
Reference Type:
secondary source
Title:
Narcotic and toxic potency of aliphatic alcohols upon rabbits
Author:
Munch JC and Schwartze EW
Year:
1972
Bibliographic source:
Ind. Med. 41, 31-33
Reference Type:
secondary source
Title:
No information
Author:
RIFM
Year:
2009
Bibliographic source:
RIFM database
Reference Type:
secondary source
Title:
No information
Author:
NIOSH
Year:
2008
Bibliographic source:
RTECS

Materials and methods

Principles of method if other than guideline:
acute oral toxicity study
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Isoamylalcohol

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: from regular dealers
- Weight at study initiation: 1.5 - 2.5 kg
- Fasting period before study: alfalfa hay and oats ad libitum, and carrots were offered several times a week.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
physiological saline
Details on oral exposure:
VEHICLE
- Amount of vehicle (if gavage): 5 ml
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 24 h
- Frequency of observations and weighing: continual observation
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 438 mg/kg bw
Remarks on result:
other: calculated
Sex:
male/female
Dose descriptor:
LD50
Effect level:
39 other: mmol/kg bw

Any other information on results incl. tables

Narcotic Dose (ND50) of 8 mmol/kg bw was determined as that quantity producing stupor, loss of voluntary movements in half of the rabbits.

Applicant's summary and conclusion