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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Uptake of 10 polar organic solvents during short-term respiration
Author:
Kumagai S, Oda H, Matsunaga I, Kosaka H and Akasaka S
Year:
1999
Bibliographic source:
Toxicological Sciences (formerly Fundamental & Applied Toxicology), 48(2), 255-263
Reference Type:
secondary source
Title:
No information
Author:
RIFM
Year:
2009
Bibliographic source:
RIFM database

Materials and methods

Objective of study:
excretion
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): iso-pentyl alcohol
Radiolabelling:
no

Test animals

Species:
human
Strain:
other: not applicable
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
other: air
Details on exposure:
TYPE OF INHALATION EXPOSURE: mouth only


GENERATION OF TEST ATMOSPHERE / CHAMPER DESCRIPTION
- System of generating particulates/aerosols: the subjects breathed through a mouthpiece with one-way valves. The inlet of this mouthpiece was connected to the test air in a 100-L Tedlar bag or room air. The outlet of the mouthpiece was connected to a 10-L Tedlar bag for collection of the mixed exhaled air
- Treatment of exhaust air: To avoid loss of the exhaled solvent vapor in condensed water, the connecting metal tubes, the mouthpiece and the three-way valves were kept at a constant temperature of 40 °C by means of a heating coil.
Duration and frequency of treatment / exposure:
10 minutes
Doses / concentrations
Remarks:
Doses / Concentrations:
25 ppm
No. of animals per sex per dose:
Four healthy male volunteers
Control animals:
not specified
Details on dosing and sampling:
PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: exhaled air

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
The mean respiratory rate for isoamyl alcohol was 15.3 min-1, which was slightly higher than the other solvents tested. The mean tidal volume in each solvent was from 470 to 530 ml and no significant difference was found among the solvents tested. The percentage of isoamyl alcohol in the end-exhaled air and in the mixed-exhaled air increased after the start of the test-air respiration, and reached a quasi-steady-state level within a few minutes. The speeds of these increases at the start of the test-air respiration became lower as partition coefficients of blood/air increased. The mean uptakes for the last five minutes of test air respiration were 63.0%.

Applicant's summary and conclusion