Registration Dossier
Registration Dossier
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EC number: 204-817-5 | CAS number: 126-98-7
Carcinogenicity
Administrative data
Description of key information
Non-carcinogenic (OECD 451)
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
No evidence of carcinogenicity has been demonstrated and it is unnecessary to classify the substance under the terms of Directive 67/548/EEC or GHS as reflected by Regulation (EC) 1272/2008.
Additional information
There was no evidence of carcinogenic activity by methacrylonitrile in male or female F344/N rats administered 3, 10, or 30 mg/kg during 2 year gavage studies. In male and female rats, methacrylonitrile administration caused significant increases in the incidences of non-neoplastic lesions of the nose and liver. Similar lack of carcinogenicity was shown in mice.
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