Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


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Administrative data

Description of key information

Non-carcinogenic (OECD 451)

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Justification for classification or non-classification

No evidence of carcinogenicity has been demonstrated and it is unnecessary to classify the substance under the terms of Directive 67/548/EEC or GHS as reflected by Regulation (EC) 1272/2008.

Additional information

There was no evidence of carcinogenic activity by methacrylonitrile in male or female F344/N rats administered 3, 10, or 30 mg/kg during 2 year gavage studies. In male and female rats, methacrylonitrile administration caused significant increases in the incidences of non-neoplastic lesions of the nose and liver. Similar lack of carcinogenicity was shown in mice.