Registration Dossier

Diss Factsheets

Toxicological information


Currently viewing:

Administrative data

Description of key information

Non-carcinogenic (OECD 451)

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Justification for classification or non-classification

No evidence of carcinogenicity has been demonstrated and it is unnecessary to classify the substance under the terms of Directive 67/548/EEC or GHS as reflected by Regulation (EC) 1272/2008.

Additional information

There was no evidence of carcinogenic activity by methacrylonitrile in male or female F344/N rats administered 3, 10, or 30 mg/kg during 2 year gavage studies. In male and female rats, methacrylonitrile administration caused significant increases in the incidences of non-neoplastic lesions of the nose and liver. Similar lack of carcinogenicity was shown in mice.