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Diss Factsheets
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EC number: 204-817-5 | CAS number: 126-98-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: human data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed literature data
Data source
Reference
- Reference Type:
- publication
- Title:
- The Mammalian Toxicity of Methacrylonitrile
- Author:
- Pozzani UC, Kinkead ER & King JM
- Year:
- 1 968
- Bibliographic source:
- American Industrial Hygiene Association Journal 29:202-210
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- Principles of method if other than guideline:
- Groups of eight to nine human subjects were exposed by inhalation twice to a series of methacrylonitrile concentrations for periods of 1 minute each, with 45-minute or longer intervals between exposures. The exposure concentrations were 24, 14, 0, 7, 14, 24, 7, 2, 0 and 2 ppm (in that order).
- GLP compliance:
- no
- Remarks:
- study predates GLP
Test material
- Reference substance name:
- Methacrylonitrile
- EC Number:
- 204-817-5
- EC Name:
- Methacrylonitrile
- Cas Number:
- 126-98-7
- Molecular formula:
- C4H5N
- IUPAC Name:
- 2-methylprop-2-enenitrile
- Details on test material:
- - Name of test material (as cited in study report): Methacrylonitrile
- Source: Vistron Corporation, Midland Building, Cleveland, Ohio
- Molecular weight: 67.09
- Substance type: organic, monoconstituent
- Physical state: clear, colourless liquid
- Analytical purity: minimum of 99.0 wt %
- Boiling point: 90.3 degrees Centigrade at 760 mm
- Specific gravity: d 30°/4°, 0.7896
- Solubility in water: 2.54 wt % at 30 degrees Centigrade
- Flash point (Tag open cup): 55 degrees Fahrenheit
- Vapor pressure: 65 mm at 25 degrees Centigrade
- Inhibitor (MEHQ): 35-45 ppm
- Other: Air saturated with methacrylonitrile at 25 degrees Centigrade at 760 mm contains 85,526 ppm vapour, which has a relative vapour density of 1.11 (dry air=1)
Constituent 1
Test animals / tissue source
- Species:
- human
- Strain:
- other: not applicable
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- In the first study, groups of eight to nine subjects were exposed to methacrylonitrile vapour at 0, 2, 7, 14 and 24 ppm. In the second study, subjects were exposed to 2 ppm or 14 ppm.
- Duration of treatment / exposure:
- First study - 1 min with intervals of 45 min or longer
Second study - 10 min - Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- First study - 7 to 9 subjects per exposure group
Second study - 9 subjects (2 ppm) or 7 subjects (14 ppm)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- other: no data
- Time point:
- other: ≥ 1 min
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: 22 % of subjects experienced eye irritation when exposed to 24 ppm for 1 min. No irritation was reported at lower concentrations.
- Irritation parameter:
- overall irritation score
- Basis:
- other: no data
- Time point:
- other: ≥ 10 min
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: only 1-2 subjects experienced eye irritation when exposed to 2 ppm or 14 ppm for 10 min
- Irritant / corrosive response data:
- No data
- Other effects:
- First study - 6 % of subjects experienced nasal irritation when exposed to 24 ppm for 1 min
First study - 17 % of subjects experienced throat irritation when exposed to 24 ppm for 1 min
Second study - only 1-2 subjects experienced any form of nasal, throat or eye irritation
Applicant's summary and conclusion
- Conclusions:
- Eye irritation was experienced by 22 % of human subjects when exposed to 24 ppm for 1 min. No eye irritation was reported for 1 min exposure at at lower concentrations. However, methacrylonitrile caused irritation of the nose, throat or eyes in some subjects at concentrations of 2 ppm and 14 ppm when the exposure period was increased to 10 minutes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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