Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-817-5 | CAS number: 126-98-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative toxicity of methacrylonitrile and acrylonitrile
- Author:
- McOmie WA
- Year:
- 1 949
- Bibliographic source:
- Journal of Industrial Hygiene and Toxicology 31(2): 113-116
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- Principles of method if other than guideline:
- Administration of methacrylonitrile to mice via the intraperitoneal route
- GLP compliance:
- no
- Remarks:
- study predates GLP
- Limit test:
- yes
Test material
- Reference substance name:
- Methacrylonitrile
- EC Number:
- 204-817-5
- EC Name:
- Methacrylonitrile
- Cas Number:
- 126-98-7
- Molecular formula:
- C4H5N
- IUPAC Name:
- 2-methylprop-2-enenitrile
- Details on test material:
- - Source: Shell Development Company (Emeryville, California)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- No data
- Doses:
- 10, 15, 20 and 72 mg/kg
- No. of animals per sex per dose:
- Two
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- 15 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No data
- Clinical signs:
- No data
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Conclusions:
- The approximate lethal dose for mice was reported as 15 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
