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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
no data
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Significant methodological deficiencies

Data source

Reference
Reference Type:
publication
Title:
Comparative toxicity of methacrylonitrile and acrylonitrile
Author:
McOmie WA
Year:
1949
Bibliographic source:
Journal of Industrial Hygiene and Toxicology 31(2): 113-116

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
Deviations:
not specified
Principles of method if other than guideline:
Administration of methacrylonitrile to mice via the intraperitoneal route
GLP compliance:
no
Remarks:
study predates GLP
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylonitrile
EC Number:
204-817-5
EC Name:
Methacrylonitrile
Cas Number:
126-98-7
Molecular formula:
C4H5N
IUPAC Name:
methacrylonitrile
Details on test material:
- Source: Shell Development Company (Emeryville, California)

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on exposure:
No data
Doses:
10, 15, 20 and 72 mg/kg
No. of animals per sex per dose:
Two
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
15 mg/kg bw
Based on:
test mat.
Mortality:
No data
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Conclusions:
The approximate lethal dose for mice was reported as 15 mg/kg bw