Registration Dossier
Registration Dossier
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EC number: 204-817-5 | CAS number: 126-98-7
Endpoint summary
Administrative data
Description of key information
Moderately irritating to rabbit skin (worst case scenario from weight of evidence provided by published data)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
SKIN IRRITATION
The substance is considered to be described by the GHS category Skin Mild Irrit 3. However, further animal testing is contraindicated by clear systemic toxicity, and available data suggest that methacrylonitrile does not meet criteria for classification as a skin irritant under the terms of Directive 67/548/EEC or GHS as reflected by Regulation (EC) 1272/2008, which does not recognise the category Skin Mild Irrit 3.
EYE IRRITATION
Published data indicates that methacrylonitrile is a mild or moderate irritant to rabbit eyes. Eye irritation was also experienced by 22 % of human subjects when exposed to 24 ppm for 1 min even though no irritation was noted at lower concentrations. Further data shows that methacrylonitrile caused irritation of the nose, throat or eyes in some subjects at concentrations of 2 ppm and 14 ppm when the exposure period was increased to 10 minutes.
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
SKIN IRRITATION
The substance is considered to be described by the GHS category Skin Mild Irrit 3. However, available data suggest that methacrylonitrile does not meet criteria for classification as a skin irritant under the terms of Directive 67/548/EEC or GHS as reflected by Regulation (EC) 1272/2008, which does not recognise the category Skin Mild Irrit 3, and further animal testing is contraindicated by clear systemic toxicity.
EYE IRRITATION
Available data suggest that methacrylonitrile does not meet criteria for classification as an eye irritant under the terms of Directive 67/548/EEC or GHS as reflected by Regulation (EC) 1272/2008. However, further animal testing is contraindicated by clear systemic toxicity and the availability of human data showing variation of irritation response between subjects.
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