Registration Dossier
Registration Dossier
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EC number: 204-817-5 | CAS number: 126-98-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed handbook and literature data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Industrial Hygiene and Toxicology, 2nd ed, vol.II
- Author:
- Fassett DW & Irish DD
- Year:
- 1 963
- Bibliographic source:
- Wiley-Interscience, NY 2012-2013
- Reference Type:
- review article or handbook
- Title:
- Industrial Hygiene and Toxicology, 3 rd. ed
- Author:
- Hartung R
- Year:
- 1 982
- Bibliographic source:
- Cited in Clayton GD, Clayton, FE Patty's Industrial Hygiene and Toxicology, 3 rd. ed, John Wiley & Sons Inc., USA, ISBN: 0-471-09258, Vol 2C: 44867-4868
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Remarks:
- study predates GLP
- Type of study:
- not specified
Test material
- Reference substance name:
- Methacrylonitrile
- EC Number:
- 204-817-5
- EC Name:
- Methacrylonitrile
- Cas Number:
- 126-98-7
- Molecular formula:
- C4H5N
- IUPAC Name:
- 2-methylprop-2-enenitrile
- Details on test material:
- No data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- No data
Challengeopen allclose all
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- No data
- No. of animals per dose:
- No data
- Details on study design:
- No data
- Challenge controls:
- No data
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- not specified
- Concentration:
- No data
- No. of animals per dose:
- No data
- Details on study design:
- No data
- Positive control substance(s):
- not specified
- Statistics:
- No data
Results and discussion
- Positive control results:
- No data
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: No data
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: No data
Any other information on results incl. tables
Experimental data is lacking from handbooks available. However, further animal testing is contraindicated by clear systemic toxicity and risk management measures designed to prevent exposure.
Applicant's summary and conclusion
- Conclusions:
- Methacrylonitrile is reported to be non-sensitising in the guinea pig
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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