Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer reviewed handbook and literature data

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Industrial Hygiene and Toxicology, 2nd ed, vol.II
Author:
Fassett DW & Irish DD
Year:
1963
Bibliographic source:
Wiley-Interscience, NY 2012-2013
Reference Type:
review article or handbook
Title:
Industrial Hygiene and Toxicology, 3 rd. ed
Author:
Hartung R
Year:
1982
Bibliographic source:
Cited in Clayton GD, Clayton, FE Patty's Industrial Hygiene and Toxicology, 3 rd. ed, John Wiley & Sons Inc., USA, ISBN: 0-471-09258, Vol 2C: 44867-4868

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
Deviations:
not specified
Principles of method if other than guideline:
No data
GLP compliance:
no
Remarks:
study predates GLP
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylonitrile
EC Number:
204-817-5
EC Name:
Methacrylonitrile
Cas Number:
126-98-7
Molecular formula:
C4H5N
IUPAC Name:
methacrylonitrile
Details on test material:
No data

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: no data
Vehicle:
no data
Concentration / amount:
No data
Challengeopen allclose all
Route:
other: no data
Vehicle:
no data
Concentration / amount:
No data
No. of animals per dose:
No data
Details on study design:
No data
Challenge controls:
No data
Positive control substance(s):
not specified

Study design: in vivo (LLNA)

Vehicle:
not specified
Concentration:
No data
No. of animals per dose:
No data
Details on study design:
No data
Positive control substance(s):
not specified
Statistics:
No data

Results and discussion

Positive control results:
No data

In vivo (LLNA)

Resultsopen allclose all
Parameter:
SI
Remarks on result:
other: No data
Parameter:
other: disintegrations per minute (DPM)
Remarks on result:
other: No data

Any other information on results incl. tables

Experimental data is lacking from handbooks available. However, further animal testing is contraindicated by clear systemic toxicity and risk management measures designed to prevent exposure.

Applicant's summary and conclusion

Conclusions:
Methacrylonitrile is reported to be non-sensitising in the guinea pig