Registration Dossier
Registration Dossier
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EC number: 204-817-5 | CAS number: 126-98-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature, cited in SIDS (2002), original study report not available
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Robust Summary Methacrylonitrile CAS No. 126-98-7. Sponsor Country Japan
- Author:
- SIDS
- Year:
- 2 002
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 14 (26 - 28 March 2002, Paris, France)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- Principles of method if other than guideline:
- Draize Test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methacrylonitrile
- EC Number:
- 204-817-5
- EC Name:
- Methacrylonitrile
- Cas Number:
- 126-98-7
- Molecular formula:
- C4H5N
- IUPAC Name:
- 2-methylprop-2-enenitrile
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 200 mg
- Duration of treatment / exposure:
- No data
- Observation period:
- No data
- Number of animals:
- No data
- Details on study design:
- No data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: result of test
- Remarks on result:
- other: moderately irritating
- Irritant / corrosive response data:
- No data
- Other effects:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information
- Conclusions:
- Methacrylonitrile is reported to be moderately irritating to rabbit skin
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