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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature, cited in SIDS (2002), original study report not available

Data source

Reference
Reference Type:
secondary source
Title:
Robust Summary Methacrylonitrile CAS No. 126-98-7. Sponsor Country Japan
Author:
SIDS
Year:
2002
Bibliographic source:
SIDS Initial Assessment Report for SIAM 14 (26 - 28 March 2002, Paris, France)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
Deviations:
not specified
Principles of method if other than guideline:
Draize Test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylonitrile
EC Number:
204-817-5
EC Name:
Methacrylonitrile
Cas Number:
126-98-7
Molecular formula:
C4H5N
IUPAC Name:
methacrylonitrile
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
200 mg
Duration of treatment / exposure:
No data
Observation period:
No data
Number of animals:
No data
Details on study design:
No data

Results and discussion

In vivo

Results
Irritation parameter:
other: result of test
Remarks on result:
other: moderately irritating
Irritant / corrosive response data:
No data
Other effects:
No data

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information
Conclusions:
Methacrylonitrile is reported to be moderately irritating to rabbit skin