Registration Dossier
Registration Dossier
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EC number: 204-817-5 | CAS number: 126-98-7
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: chronic oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only
Data source
Reference
- Reference Type:
- publication
- Title:
- Relative neurotoxicological properties of five unsaturated aliphatic nitriles in rats
- Author:
- Gagnaire F, Marignac B & Bonnet P
- Year:
- 1 988
- Bibliographic source:
- Journal of Applied Toxicology, 18(1): 25-31
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- Principles of method if other than guideline:
- Neurophysiological measurement during repeated dose oral administration of methacrylonitrile
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Methacrylonitrile
- EC Number:
- 204-817-5
- EC Name:
- Methacrylonitrile
- Cas Number:
- 126-98-7
- Molecular formula:
- C4H5N
- IUPAC Name:
- 2-methylprop-2-enenitrile
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on exposure:
- Five days per week
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data
- Duration of treatment / exposure:
- Twelve weeks
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 70 or 90 mg/kg bw
Basis:
no data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- Neurophysiological measurement was performed with a Racia-Medelec modular electrophysiological system, equipped with a DAV 62 computer.
Examinations
- Observations and clinical examinations performed and frequency:
- At least 16 hours after treatment during weeks 3, 6, 9, and 12 of exposure plus week 20 (8 weeks after exposure ended).
- Specific biochemical examinations:
- No data
- Neurobehavioural examinations performed and frequency:
- The motor conduction velocity of the tail nerves were measured together with the amplitudes of the sensory action potential and of the muscular action potential.
- Sacrifice and (histo)pathology:
- No data
- Other examinations:
- No data
- Positive control:
- No data
- Statistics:
- No data
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- mortality observed in 50 and 90 mg/kg groups
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- mortality observed in 50 and 90 mg/kg groups
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- significant decrease in 70 and 90 mg/kg groups
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Behaviour (functional findings):
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Other effects:
- not specified
- Description (incidence and severity):
- Migrated information from 'Further observations for developmental neurotoxicity study'
Details on results (for developmental neurotoxicity):No data (migrated information) - Details on results:
- Two rats died in the low dose group and eight rats died in the high dose group. Body weight was significantly decreased at 70 and 90 mg/kg. However, no abnormal behaviours were seen, and there were no significant changes in motor and senory conduction velocities and amplitudes of the sensory and motor potentials of the tail nerve.
Applicant's summary and conclusion
- Conclusions:
- There were no significant changes in motor and sensory conduction velocities and amplitudes of the sensory and motor potentials of the tail nerve during or after administration of methacrylonitrile to rats for 12 weeks.
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