Registration Dossier
Registration Dossier
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EC number: 204-817-5 | CAS number: 126-98-7
Classification & Labelling & PBT assessment
GHS
General Information
- Name:
- Methacrylonitrile
- Implementation:
- EU
- Remarks:
- Regulation (EC) 1272/2008 states that harmonised classifications should be regarded as the minimum and, where a manufacturer or importer has access to data or other information that lead to classification in a more severe category, classification in the more severe category must be applied.
ACUTE INHALATION TOXICITY
The key study reports the LD50 for acute inhalation toxicity as 496 ppm in female rats and 398 ppm in male rats. The lowest (most conservative) value of 398 ppm is equivalent to 1092 mg/cubic metre or 1.09 mg/L, which leads to classification as acute toxicity - inhalation category 2.
Related composition
- Related composition:
- methacrylonitrile
Classificationopen allclose all
Explosives
- Reason for no classification:
- data conclusive but not sufficient for classification
Flammable gases and chemically unstable gases
- Reason for no classification:
- data lacking
Aerosols
- Reason for no classification:
- data lacking
Oxidising gases
- Reason for no classification:
- data lacking
Gases under pressure
- Reason for no classification:
- data lacking
Flammable liquids
- Hazard category:
- Flam. Liquid 2
- Hazard statement:
- H225: Highly flammable liquid and vapour.
Flammable solids
- Reason for no classification:
- data lacking
Self-reactive substances and mixtures
- Reason for no classification:
- data lacking
Pyrophoric liquids
- Reason for no classification:
- data lacking
Pyrophoric solids
- Reason for no classification:
- data lacking
Self-heating substances and mixtures
- Reason for no classification:
- data lacking
Substances and mixtures which in contact with water emit flammable gases
- Reason for no classification:
- data lacking
Oxidising liquids
- Reason for no classification:
- data conclusive but not sufficient for classification
Oxidising solids
- Reason for no classification:
- data lacking
Organic peroxides
- Reason for no classification:
- data lacking
Corrosive to metals
- Reason for no classification:
- data lacking
Desensitized explosives
- Reason for no classification:
- data lacking
Acute toxicity - oral
- Hazard category:
- Acute Tox. 3
- Hazard statement:
- H301: Toxic if swallowed.
Acute toxicity - dermal
- Hazard category:
- Acute Tox. 3
- Hazard statement:
- H311: Toxic in contact with skin.
Acute toxicity - inhalation
- Hazard category:
- Acute Tox. 2
- Hazard statement:
- H330: Fatal if inhaled.
Skin corrosion / irritation
- Reason for no classification:
- data conclusive but not sufficient for classification
Serious eye damage / eye irritation
- Reason for no classification:
- data conclusive but not sufficient for classification
Respiratory sensitisation
- Reason for no classification:
- data lacking
Skin sensitisation
- Hazard category:
- Skin Sens. 1
- Hazard statement:
- H317: May cause an allergic skin reaction.
Aspiration hazard
- Reason for no classification:
- data lacking
Reproductive toxicity
- Reason for no classification:
- data conclusive but not sufficient for classification
Effects on or via lactation
- Reason for no classification:
- data lacking
Germ cell mutagenicity
- Reason for no classification:
- data conclusive but not sufficient for classification
Carcinogenicity
- Reason for no classification:
- data conclusive but not sufficient for classification
1. Specific target organ toxicity - single (STOT-SE)
- Hazard category:
- STOT Single Exp. 1
- Hazard statement:
- H370: Causes damage to organs <or state all organs affected, if known> <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Affected organs:
- other: Central nervous system
1. Specific target organ toxicity - repeated (STOT-RE)
- Reason for no classification:
- data conclusive but not sufficient for classification
1.
- Concentration range (%):
- >= 0.2
- Hazard categories:
- Skin Sens. 1
Hazardous to the aquatic environment (acute / short-term)
- Reason for no classification:
- data conclusive but not sufficient for classification
Hazardous to the aquatic environment (long-term)
- Reason for no classification:
- data conclusive but not sufficient for classification
Hazardous to the ozone layer
- Reason for no classification:
- data lacking
Labelling
- Signal word:
- Danger
Hazard pictogram
- GHS02: flame
- GHS06: skull and crossbones
- GHS08: health hazard
Hazard statements
- H225: Highly flammable liquid and vapour.
- H301: Toxic if swallowed.
- H311: Toxic in contact with skin.
- H330: Fatal if inhaled.
- H370: Causes damage to organs <or state all organs affected, if known> <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Central nervous system
- H317: May cause an allergic skin reaction.
Precautionary statements
- P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P233: Keep container tightly closed.
- P240: Ground and bond container and receiving equipment.
- P241: Use explosion-proof [electrical/ventilating/lighting/...] equipment.
- P242: Use non-sparking tools.
- P243: Take actions to pevent static discharges.
- P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
- P303+P361+P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].
- P302+P352: IF ON SKIN: Wash with plenty of water/…
- P370+P378: In case of fire: Use... to extinguish.
- P403+P235: Store in a well-ventilated place. Keep cool.
- P501: Dispose of contents/container to ...
- P264: Wash ... thoroughly after handling.
- P270: Do not eat, drink or smoke when using this product.
- P301+P310: IF SWALLOWED: Immediately call a POISON CENTER/doctor/…
- P321: Specific treatment (see ... on this label).
- P330: Rinse mouth.
- P405: Store locked up.
- P322: Specific measures (see ... on this label).
- P363: Wash contaminated clothing before reuse.
- P272: Contaminated work clothing should not be allowed out of the workplace.
- P260: Do not breathe dust/fume/gas/mist/vapours/spray.
- P271: Use only outdoors or in a well-ventilated area.
- P284: [In case of inadequate ventilation] wear respiratory protection.
- P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P320: Specific treatment is urgent (see ... on this label).
- P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
- P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
Notes
- Note D
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
