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Carcinogenicity

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Description of key information

No evidence of carcinogenicity was seen in a 2-year dietary study in rats or in an 80 week dietary study in mice. 

Key value for chemical safety assessment

Justification for classification or non-classification

Cloquintocet-mexyl is considered not to be carcinogenic and no classification is warranted:

- under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC, Annex VI, 4.2.1.

- under Regulation (EC) 1272/2008, Annex I, Part 3, 3.6.2.

Additional information

Dietary studies in rats (Fankhauser, 1992) and mice (Fankhauser, 1992) have been performed. No evidence of carcinogenicity was seen at the highest dose tested in either species. In rats, hyperplastic changes were seen in the thymus of males at 2000 ppm and of the thyroid gland in the females at 1000 and 2000 ppm. Dietary administration to mice over 18 months resulted in reduced body weights in both sexes, lower food consumption in females, increased water consumption in both sexes and chronic inflammatory changes in the urinary bladder in males at 5000 ppm. No statistically significant treatment-related increase in any tumour type was seen in either study.