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EC number: 619-447-3 | CAS number: 99607-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09.02.1987 to 03.03.1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate
- EC Number:
- 619-447-3
- Cas Number:
- 99607-70-2
- Molecular formula:
- C18H22ClNO3
- IUPAC Name:
- heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate
- Details on test material:
- - Name of test material (as cited in study report): CGA185072 (company code)
- Name of test material (as cited in study report): CGA185072 technical or cloquintocet-mexyl
- Molecular formula (if other than submission substance): not stated
- Substance type:
- Physical state:
- Analytical purity: 91.6%
- Purity test date: not specified
- Lot/batch No.: P. 607001/002
- Expiration date of the lot/batch: not specifed
- Stability under test conditions: not specified
- Storage condition of test material: not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif RAIf (SPF), Sprague-Dawley derived
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ciba-Geigy Ltd, Animal Production, Sisseln, Switzerland
- Age at study initiation: 7 - 8 weeks
- Weight at study initiation: 162-212g
- Fasting period before study: Not specified
- Housing: conventional laboratory cages
- Diet (e.g. ad libitum): Not specified
- Water (e.g. ad libitum): Not specified
- Acclimation period: 5 days
IN-LIFE DATES: From: 09.02.1987 To: 03.03.1987
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- The test material was admixed to distilled water containing 0.5% CMC and 0.1% polysorbate 80.
The dosing solution was prepared immediately before administration. The stability was therefore not checked. 10 ml of the solution per kg body weight were applied by gastric intubation. The highest dose group received 20 ml/kg body weight due to the poor solubility of the test material. - Doses:
- 2000 or 5000 mg/kg bw
- No. of animals per sex per dose:
- Five per sex per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: obsrved hourly for 5 h on day of dosing and twice daily subsequently. Bodyweights recorded pre-test and at weekly intervals
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Not applicable - median lethal dose exceeded Guideline limit dose of 2000 mg/kg bw
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - ca. 5 000 mg/kg bw
- Remarks on result:
- other: None of the rats dosed at 2000 mg/kg bw died. One of four males dosed at 5000 mg/kg bw died and two of five females.
- Mortality:
- None of the rats dosed at 2000 mg/kg bw died. One of four males dosed at 5000 mg/kg bw died and two of five females at the higher dose level.
- Clinical signs:
- Dyspnea, exophthalmus, ruffled fur and curved body positions were observed in all animals. Recovery was evident by day 13.
- Body weight:
- No information
- Gross pathology:
- No macroscopic abnormalities noted among rats dosed at 2000 mg/kg bw
Haemorrhagic lungs and stomachs for one male and two females dosed at 5000 mg/kg bw. Intestinal dilation noted for one female - Other findings:
- None
Any other information on results incl. tables
One male dosed at 5000 mg/kg bw died on day 2, the two females decedents died on days 1 and 3.
Dose |
Mortality |
Day of death |
2000 mg/kg |
0/ 5 |
|
2000 mg/kg |
0 / 5 |
|
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 greater than 5000 mg/kg bw
- Executive summary:
Groups of Tif RAIf (SPF), Sprague-Dawley derived rats were dosed with CGA185072 technical, purity 91.6% at doses of 2000 or 5000 mg/kg test material in 0.5% aqueous CMC and 0.1% polysorbate 80.The animals were assessed daily for the following 14 days for any signs of systemic toxicity and their bodyweights recorded at intervals throughout the study.After 14 days surviving rats were sacrificed and subjected to gross necropsy as were those rats which died spontaneously. Dyspnea, exophthalmus, ruffled fur and curved body positions were observed in all animals. At 5000 mg/kg bw one male and two females died. Surviving animals recovered within 13 days. At necropsy, no macroscopic abnormalities were found at 2000 mg/kg. At 5000 mg/kg one male and 2 females showed hemorrhagic lungs and a hemorrhagic stomach. The small intestine of one female was dilated.
The acute oral LD50 of CGA185072 tech. is greater than 5000 mg/kg in male and female rats.
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