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EC number: 619-447-3 | CAS number: 99607-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 March 1987 to 26 May 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Using the available equipment it was not possible to generate an atmosphere with a concentration of greater than 935 ug/m3
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate
- EC Number:
- 619-447-3
- Cas Number:
- 99607-70-2
- Molecular formula:
- C18H22ClNO3
- IUPAC Name:
- heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate
- Details on test material:
- - Name of test material (as cited in study report): CGA185072 technical
- Physical state: solid, powder
- Analytical purity: 91.6%
- Expiration date of the lot/batch: Not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 6-8 weeks
- Weight at study initiation: circa 200 g
- Fasting period before study: None specified
- Housing: Conventional laboratory cages
- Diet (e.g. ad libitum): not specified
- Water (e.g. ad libitum): Not specified
- Acclimation period: 5 days
IN-LIFE DATES: From: 12.03.1987 To: 26.05.1987
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: aerosol generated using Wright dust generator
- Exposure chamber volume: not specified
- Method of holding animals in test chamber: nose-only exposure restraint tubes
- Source and rate of air: flow rate for air supply was 25 L/min
- Method of conditioning air: not specified
- System of generating particulates/aerosols: Wright dust generator
- Method of particle size determination: two samples taken duriing exposure using Cascade impactor
- Treatment of exhaust air: not specified
- Temperature, humidity, pressure in air chamber: temperature - 22.0 +/- 0.1C; Humidity 42+/-2% RH
TEST ATMOSPHERE
- Samples taken from breathing zone: yes
VEHICLE
- Composition of vehicle (if applicable): air
- Concentration of test material in vehicle (if applicable): Nominal concentration = 935 mg/m3 and gravimetrically determined concentration = 935+/-482 mg/m3
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: see tabulated results
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- The maximum possible concentration that could be achieved for this test material under the conditions of the test was 935 mg/m3. From gravimetric analysis it was determined that in excess of 70% of the dust generated was respirable.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed twice daily for 14 days. Bodyweights recorded pre-test and at weekly intervals subsequently
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, food consumption - Statistics:
- No statistical analysis as the median lethal dose concentration exceeded the maximum atmosphere concentration that could be generated.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 935 mg/m³ air
- Based on:
- other: nominal concentration
- Exp. duration:
- 4 h
- Remarks on result:
- other: One male only (of five males and five females) died.
- Mortality:
- One male died immediately after removal from the exposure chamber
- Clinical signs:
- other: Dyspnoea, lethargy and brown stains around the snout were observed in most treated animals
- Body weight:
- All animals gained weight during the study
- Gross pathology:
- The stomach of the rat which died was distended with gas. There were no other macroscopic abnormalities observed
- Other findings:
- None
Any other information on results incl. tables
Dose |
Mortality |
Control group 935 mg/m3 |
0 / 5 1 / 5 |
Control group 935 mg/m3 |
0 / 5 0 / 5 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The inhalation LC50 in rats was greater than 935 mg/m3 (the maximum practical atmosphere concentration that could be generated).
- Executive summary:
CGA185072 technical, purity 91.6%, batch P. 607001/002, was administered by inhalation exposure to Wistar rats 6 -8 weeks old at study initiation. There were 5 males and 5 females in the treated group and a further group of controls. An atmosphere was generated by a Wright dust generator, which scraped the test material from the surface of a compressed powder in a stream of air (flow rate 25 l/min). The maximum concentration which could be generated was 935 mg/m3. The animals were exposed for 4 hours in a nose-only chamber. Animals were observed twice daily for 14 days. Body weights and food consumption were recorded pretest and weekly thereafter. After 14 days surviving animals were sacrificed and subjected to gross necropsy. Lung weights were recorded. One male died immediately following completion of the exposure period. The remaining nine rats survived. Clinical observations included dyspnoea, lethargy and brown stains around the snout. All rats gained weight and no necropsy abnormalities were seen. The inhalation LC50 was greater than 935 mg/m3.
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