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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Guideline GLP acute toxicity studies are available for cloquintocet-mexyl technical (purity 91.6 or 96.7%) for the oral, inhalation and dermal routes of exposure. Data indicate that acute toxicity is expected to be low. Cloquintocet-mexyl  does not pose an acute hazard following oral (oral LD50 > 5000 mg/kg), skin contact (dermal LD50 > 2000 mg/kg) or acute inhalation (4 hour LC50 935 mg/m3) exposures and does not warrant classification for acute toxicity.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
935 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Non-human information

Acute oral toxicity data for cloquintocet-mexyl indicate an oral LD50 value in rats of > 5000 mg/kg (Hartmann HR, 1987). The acute oral toxicity in mice is > 2000 mg/kg (Hartmann HR, 1991). A four hour acute inhalation toxicity study in rats showed no acute inhalation toxicity showed at the highest achievable concentration of 935 mg/m3 (Jackson GC, 1987). An acute dermal toxicity study gave an acute dermal LD50 value in rabbits of > 2000 mg/kg (Hartmann HR, 1987).  

Human information

There are no studies on the oral, inhalation or dermal toxicity in humans for cloquintocet-mexyl.

Justification for classification or non-classification

There are sufficient data on cloquintocet-mexyl to indicate that the substance is of low acute toxicity by the oral, dermal and inhalation routes and does not warrant classification for acute toxicity:

- under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC, Annex VI, 3.2.

- under Regulation (EC) 1272/2008, Annex I, Part 3, 3.1.2.