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EC number: 619-447-3 | CAS number: 99607-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Guideline GLP acute toxicity studies are available for cloquintocet-mexyl technical (purity 91.6 or 96.7%) for the oral, inhalation and dermal routes of exposure. Data indicate that acute toxicity is expected to be low. Cloquintocet-mexyl does not pose an acute hazard following oral (oral LD50 > 5000 mg/kg), skin contact (dermal LD50 > 2000 mg/kg) or acute inhalation (4 hour LC50 935 mg/m3) exposures and does not warrant classification for acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 935 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Non-human information
Acute oral toxicity data for cloquintocet-mexyl indicate an oral LD50 value in rats of > 5000 mg/kg (Hartmann HR, 1987). The acute oral toxicity in mice is > 2000 mg/kg (Hartmann HR, 1991). A four hour acute inhalation toxicity study in rats showed no acute inhalation toxicity showed at the highest achievable concentration of 935 mg/m3 (Jackson GC, 1987). An acute dermal toxicity study gave an acute dermal LD50 value in rabbits of > 2000 mg/kg (Hartmann HR, 1987).
Human information
There are no studies on the oral, inhalation or dermal toxicity in humans for cloquintocet-mexyl.
Justification for classification or non-classification
There are sufficient data on cloquintocet-mexyl to indicate that the substance is of low acute toxicity by the oral, dermal and inhalation routes and does not warrant classification for acute toxicity:
- under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC, Annex VI, 3.2.
- under Regulation (EC) 1272/2008, Annex I, Part 3, 3.1.2.
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