Registration Dossier
Registration Dossier
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EC number: 619-447-3 | CAS number: 99607-70-2
Endpoint summary
Administrative data
Description of key information
Guideline GLP acute toxicity studies are available for cloquintocet-mexyl technical (purity 91.6 or 96.7%) for the oral, inhalation and dermal routes of exposure. Data indicate that acute toxicity is expected to be low. Cloquintocet-mexyl does not pose an acute hazard following oral (oral LD50 > 5000 mg/kg), skin contact (dermal LD50 > 2000 mg/kg) or acute inhalation (4 hour LC50 935 mg/m3) exposures and does not warrant classification for acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 935 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Non-human information
Acute oral toxicity data for cloquintocet-mexyl indicate an oral LD50 value in rats of > 5000 mg/kg (Hartmann HR, 1987). The acute oral toxicity in mice is > 2000 mg/kg (Hartmann HR, 1991). A four hour acute inhalation toxicity study in rats showed no acute inhalation toxicity showed at the highest achievable concentration of 935 mg/m3 (Jackson GC, 1987). An acute dermal toxicity study gave an acute dermal LD50 value in rabbits of > 2000 mg/kg (Hartmann HR, 1987).
Human information
There are no studies on the oral, inhalation or dermal toxicity in humans for cloquintocet-mexyl.
Justification for classification or non-classification
There are sufficient data on cloquintocet-mexyl to indicate that the substance is of low acute toxicity by the oral, dermal and inhalation routes and does not warrant classification for acute toxicity:
- under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC, Annex VI, 3.2.
- under Regulation (EC) 1272/2008, Annex I, Part 3, 3.1.2.
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