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EC number: 619-447-3 | CAS number: 99607-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 December 1987 to 03 March 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate
- EC Number:
- 619-447-3
- Cas Number:
- 99607-70-2
- Molecular formula:
- C18H22ClNO3
- IUPAC Name:
- heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate
- Details on test material:
- - Name of test material (as cited in study report): CGA185072 technical
- Physical state: solid
- Analytical purity: 91.6%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: not specified
- Age at study initiation: 12-14 weeks
- Weight at study initiation: 2180 to 2550 g
- Housing: conventional laboratory housing units not otherwise specified
- Diet (e.g. ad libitum): not specified
- Water (e.g. ad libitum): not specified
- Acclimation period: not specified
IN-LIFE DATES: From: 24.02.1987 To: 03.03.1987
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- The report indicates 0.1 mL (a weight of 48 mg) was instilled into each treated eye
- Duration of treatment / exposure:
- The eyes were examined over a period of 7 days. No rinse out procedures were included to flush the test material away at any point
- Observation period (in vivo):
- Observation and assessment of ocular damage completed at 1, 24, 48 and 72 hours post-instillation and again after 7 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: Standard Draize method
TOOL USED TO ASSESS SCORE: None specified - simple visual checks only
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Slight reactions observed in all three rabbits at 1, 24 and 48 hour assessments
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: Not applicable.
- Remarks on result:
- other: No iridial changes were apparent
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1.2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Slight to well defined erythema evident for all three treated eyes at assessments in first 48 hours after instillation. All reactions had resolved within 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Very slight to slight chemosis evident for all three treated eyes in the first 48 hours after dosing. Fully recovered by the 72 hour assessment
- Irritant / corrosive response data:
- Signs of irritation were evident 1, 24 and 48 hours following instillation affecting the conjunctivae and cornea. No adverse effects noted for the iris.
All signs of irritation had resolved within 72 hours
Any other information on results incl. tables
Table 1: Summary of results
Cornea |
Iris |
|||||
Animal no. |
1 M |
2 M |
3 M |
1 M |
2 M |
3 M |
after 1 hour |
1 |
0 |
0 |
0 |
0 |
0 |
after 24 hours |
1 |
1 |
1 |
0 |
0 |
0 |
after 48 hours |
1 |
1 |
1 |
0 |
0 |
0 |
after 72 hours after 7 days |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
mean score 24, 48, 72 h |
0.67 |
0 |
||||
Conjunctival redness |
Conjunctival chemosis |
|||||
after 1 hour |
1 |
1 |
1 |
2 |
1 |
2 |
after 24 hours |
2 |
2 |
2 |
1 |
1 |
1 |
after 48 hours |
2 |
1 |
2 |
1 |
1 |
1 |
after 72 hours after 7 days |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
mean score 24, 48, 72 h |
1.2 |
0.67 |
||||
M: Male |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Cloquintocet-mexyl does not trigger classification for eye irritation.
- Executive summary:
To evaluate eye irritation potential, 0.1 mL (48 mg) of cloquintocet-mexyl technical, purity 91.6%, batch P. 607001/002 was placed into the conjunctival sac of one eye of three male New Zealand White Rabbits. Ocular reactions were evaluated at 1, 24, 48, and 72 hours and 7 days following treatment. The results showed transient slight irritating effects in the cornea and conjunctivae that had fully resolved within 72 hours. Cloquintocet-mexyl does not trigger classification for eye irritation.
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