Registration Dossier
Registration Dossier
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EC number: 619-447-3 | CAS number: 99607-70-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
- Non-human information Cloquintocet-mexyl has
been tested in an optimization study in guinea pigs conducted according to
OECD test guideline 406 (Schoch M, 1987). Groups of 20 guinea pigs were
treated with 0.1% cloquintocet-mexyl for induction and challenged with 1%
cloquintocet-mexyl. All 20 guinea pigs in the treated group showed a
positive reaction 24 and 48 hours after challenge. Cloquintocet-mexyl was
found to be a skin sensitiser. Human information There is no human
information concerning skin sensitisation.
Migrated from Short description of key information:
In a guideline, GLP skin sensitisation study in guinea pigs cloquintocet-mexyl gave a positive response in all 20 animals in the treated group. Cloquintocet-mexyl should be classified as a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No data animal or human data have been found with regard to respiratory sensitisation.
Migrated from Short description of key information:
No data animal or human data have been found with regard to respiratory sensitisation.
Justification for classification or non-classification
Data on cloquintocet-mexyl indicate that it causes an allergic skin reaction in guinea pigs and should therefore be classified as a sensitiser by skin contact:
- under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC, Annex VI, 3.2.7.2.
- under Regulation (EC) 1272/2008, Annex I, Part 3, 3.4.2.2.
There is no data on the respiratory sensitisation potential of cloquintocet-mexyl.
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