Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:
Non-human information Cloquintocet-mexyl has been tested in an optimization study in guinea pigs conducted according to OECD test guideline 406 (Schoch M, 1987). Groups of 20 guinea pigs were treated with 0.1% cloquintocet-mexyl for induction and challenged with 1% cloquintocet-mexyl. All 20 guinea pigs in the treated group showed a positive reaction 24 and 48 hours after challenge. Cloquintocet-mexyl was found to be a skin sensitiser. Human information There is no human information concerning skin sensitisation.

Migrated from Short description of key information:
In a guideline, GLP skin sensitisation study in guinea pigs cloquintocet-mexyl gave a positive response in all 20 animals in the treated group. Cloquintocet-mexyl should be classified as a skin sensitiser.

Respiratory sensitisation

Endpoint conclusion
Additional information:

No data animal or human data have been found with regard to respiratory sensitisation.


Migrated from Short description of key information:
No data animal or human data have been found with regard to respiratory sensitisation.

Justification for classification or non-classification

Data on cloquintocet-mexyl indicate that it causes an allergic skin reaction in guinea pigs and should therefore be classified as a sensitiser by skin contact:

- under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC, Annex VI, 3.2.7.2.

- under Regulation (EC) 1272/2008, Annex I, Part 3, 3.4.2.2.

There is no data on the respiratory sensitisation potential of cloquintocet-mexyl.