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EC number: 938-793-9
CAS number: -
In an acute dermal toxicity study, eight
rabbits (4 male and 4 female) were shaved free of hair 24 hours prior to
test material application and then returned to their cages for 24 hours
for recovery. The expose sites of four rabbits (2 males and 2 females)
were abraded. Minor incisions were made to the stratum corneum, but did
not disturb the dermis. A single dose of 5 mL/kg bw of #2 home heating
oil (50% cat) was applied to gauze sponges backed with Saran Wrap. These
sponges were taped to the shaved area of the rabbit's' backs with
adhesive tape. Then the entire trunk was wrapped with Conform elastic
tape and the rabbits were returned to their cages. After 24 hours the
bandaging was removed and the exposure sites were examined for
reactions. Animals were observed for mortality and other toxic effects
daily for the remainder of the study (14 days). Body weights were
recorded on days 0, 7, and 14. On day 14 all rabbits were euthanized and
subjected to gross necropsy.
One animal died on day 7, but cause of death
is not believed to be compound related. All animals showed signs of
erythema upon bandage removal. Dry cracked skin was noted in all test
animals in later observations. There were no treatment-related signs of
systemic toxicity in any rabbits during the duration of the study. Five
rabbits exhibited congested lungs, and one rabbit showed a large
maxillary abscess on the right side of its head and a slightly congested
liver. These observations are not believed to be related to the test
substance. Based on the lack of mortality, the LD50 is > 5 mL/kg bw/day
(approx > 4300 mg/kg bw/day) and the test material is not classified
according to EU regulations.
This study has a Klimisch score of 1 and is
classified as reliable without restriction because it was conducted
according to or similar to guideline study OECD 434.
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