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EC number: 938-793-9
CAS number: -
VGO/HGO/Distillate fuels were found to be irritating to the skin of rabbits after a 24-hour, occlusive exposure (similar to OECD 404). The key data showed mean erythema scores of 3.9 and 2.5, and mean oedema scores of 2.96 and 1.5. VGO/HGO/Distillate fuels were considered non-irritating to the rabbit eye (OECD 405).
studies were available to assess the skin irritation potential of
VGOs/HGOs/Distillate fuels. In
the first key study (Klimisch score = 1, API 1980a), the irritation
potential of diesel fuel to rabbits was evaluated after application to
one abraded area and one intact area per animal, under occlusion, for 24
erythema and oedema were present at both abraded and intact test sites
at 24 hours, with blistering and peeling. The
erythema was largely resolved by day 14, and the oedema was fully
resolved by day 14. The
mean 24 and 72 hour score for erythema was 3.9 and oedema was 2.96. In
the second key study (Klimisch score = 1, API 1980b), the skin
irritation potential of #2 home heating oil (50% catalytically-cracked)
to rabbits was evaluated after application to two abraded areas and two
intact areas per animal, under occlusion, for 24 hours. Moderate
erythema was present at 24 hours with all three animals, which was
increased in severity at 72 hours before declining at 7 days and fully
resolving by day 14. Moderate
oedema was also present at 24 hours, which increased to
moderate-to-severe oedema by 72 hours but fully resolving by day 14. The
mean erythema score (24 and 72 hour) score was 2.5 and the oedema was
supporting studies, rabbits were dermally exposed to VGOs/HGOs/Distillate
fuelsunder occlusive conditions for 24
hours (Klimisch scores = 2, ARCO 1993e, 1993f, 1990b, 1988e, 1987j,
1987k, 1986b, 1986c). Mean
erythema scores ranged from 1.5 to 3.25, and mean oedema scores ranged
from 1.2 to 2.65.
studies were performed with a 24 hour exposure rather than 4 hours
recommended by the current OECD guidelines. Consequently, the result
from a shorter exposure time will likely not cause as much irritation as
these records indicate. However,
based on these results and evidence of irritation in all studies,
VGOs/HGOs/Distillate fuels are classified as irritating to the skin.
studies were available to assess the eye irritation potential of
VGOs/HGOs/Distillate fuels. In
both key studies, 9 New Zealand White rabbits (5 males and 4 females)
received 0.1 mL of undiluted test material in the right eye. Treated
and control eyes from three rabbits from each study were flushed with
lukewarm water for one minute starting 30 seconds after test material
instillation. The eyes of the other 6 rabbits in each study remained
the first key study (Klimisch score = 1, API 1980a), diesel fuel was
non-irritating to the eyes of rabbits. In
the second key study (Klimisch score = 1, API 1980b),only one rabbit, in
the unrinsed group, exhibited minor conjunctival erythema at the 24 and
48 hour reading. All other animals were normal. Under the conditions of
this study, the test material exhibited no corneal opacity and the
slight irritation was reversible within seven days, indicating a
additional eye irritation supporting studies (Klimisch scores = 2, ARCO
1993g, 1992d, 1990c, 1988f, 1987l, 1986g, 1986e, 1986f), rabbits were
fuelsand observed for irritation. Any
irritation noted was fully reversible and mild.
on these results,VGOs/HGOs/Distillate
fuelsare not classified as irritating
to the rabbit eye.
Additional data support that
VGOs/HGOs/Distillate Fuels are skin irritants but not eye irritants (API,
1980aa; API, 1980bb; Beck et al., 1984; API, 1985b; API, 1985c). This
information is presented in the dossier.
mean erythema scores of 3.9 and 2.5 (24, 72 hours), and mean oedema
scores of 2.96 and 1.5 (24, 72 hours), VGOs/HGOs/Distillate Fuels are
classified as irritating to the skin, H315, according to the EU CLP
Based on a
lack of significant eye irritation, VGOs/HGOs/Distillate Fuels are not
classified as irritating to eyes according to the EU CLP Regulation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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