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EC number: 938-793-9
CAS number: -
In a repeated dose oral toxicity study Naval
distillate was administered to male and female Sprague Dawley rats at dose
levels of 0.0001, 0.005, and 0.5 mL/kg were administered 5 days/week
over a 4 week period.
The test material produced slight dermal
irritation at a dose of 0.005 mL/kg and severe irritation at a dose of
0.50 mL/kg as evidenced by grossly visible dermal irritation and
microscopic changes in the skin. A dose-dependent decrease in mean
trglyceride was noted in males at a dose of 0.50 mL/kg. No other
treatment related effects were observed in any of the parameters
evaluated. No treatment-related effects were noted in examination of the
weight and histopathology of testes and ovaries.
The NOEL level based on dermal irritation
was 0.0001 mL/kg and a NOEL of 0.5 mL/kg was calculated for systemic
This study received a Klimisch score of two
and is classified as reliable with restriction because it is an
acceptable and a well-documented study report.
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