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EC number: 938-793-9
CAS number: -
Mortality before Day 14
In an acute oral toxicity study, five groups
of ten rats (5 males and 5 females) were given a single dose of the
appropriate amount of #2 home heating oil (50% catalytically-cracked)
(10, 20 mL/kg, 22.5, 23, or 25 mL/kg) via oral gavage. Dose levels were
chosen to produce expected mortality rates between 10 and 90%. Signs of
mortality and toxicity were observed daily for the duration of the study
(14 days). Body weight was measured on days 0 and 7, and upon death.
Gross necropsy was performed on each animal when they died or by day 14.
Mortality rates of the five dose groups (10,
20, 22,5, 23, and 25 mL/kg) were 0, 30, 70, 80, and 70% respectively.
Signs of toxicity were observed in all dose groups. Severity increased
with increased dose. Common observations were oily urine stains on fur,
which resulted in hair loss, irritation, redness, and sores. In higher
doses the affected area included the entire ventral side and legs. Other
observations included blood around eyes, nose, and mouth, lethargy and
diarrhea. Gross pathology observations were also similar in each dose
group. In rats who survived for the duration of the study (14 days),
there were few abnormalities. In these rats minor observations included
enlarged Peyer's patches on intestines. Both animals that died and
survived exhibited mild irritation and congestion in the lungs, in
addition to fluid-filled abscesses in the lungs. Investigators also
observed enlarged adrenal glands of some animals. The majority of the
animals that died before day 14 showed intestinal damage including,
hemorrhaging, thinning of intestinal walls, and increased gas in the
Under the conditions of this study, the test
material had an oral LD50 of 21.2 mL/kg (approx 17,900 mg/kg) and a 95%
confidence interval of 18.7 and 24.9 mL/kg. the test material was
determined to have a median lethal dose according to the study report.
Under the conditions of this test, #2 home heating oil is considered not
classified for acute oral toxicity.
This study received a Klimisch score of 1and
is classified as reliable without restriction because it was conducted
similar to guideline study OECD 401.
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