Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 938-793-9
CAS number: -
No experimental data
were located on the toxicokinetics of gas oilsin vivo, hence
other information sources must be used to assessing the toxicokinetics
of these substancesin vivo.
experimental studies in animals provide qualitative evidence of
absorption by the lung, as indicated by a modest increase in startle
reflex in rats inhaling respirable aerosols of diesel fuel.
Physico-chemical considerations also suggest that highly respirable
aerosols of poorly water soluble substances with a log Pow greater than
zero will be absorbed to some extent from the respiratory tract. In the
absence of further guidance, it will be assumed that 50% of an inhaled
dose of aerosolised gas oil will be absorbed by animals and humans.
No measured data are
available on the dermal absorption of gas oils, however the occurrence
of systemic tissue changes in repeated dose toxicity studies (in the
absence of dermal irritation, and after controlling for incidental
ingestion during grooming) indicates that some absorption across the
skin is possible. Results from the SKINPERM model indicate that uptake
of gas oil across the skin is likely to be low, with an estimated dermal
flux of 0.0001058 mg cm-2.hour for human skin. However
the reliability of this value is not known, and therefore complete
absorption of gas oil by human skin has been assumed (conservative
default) as recommended by the TGD (ECB, 2003). This is probably highly
conservative given that the log Pow of the majority (>98.5%) of gas oil
components falls outside the 1-4 range that favours dermal uptake (ECB,
2003). Since experimental studies demonstrate greater absorption of
lipophilic substances by animal skin compared to human skin, it will be
therefore be assumed during risk characterisation that animal skin is
2-fold more permeable to topically applied gas oils than is human skin.
Substances in Vacuum
Gas Oils/Hydrocracked Gas Oils/ Distillate Fuels are UVCBs; hence it is
not possible to apply standard methodology for assessing absorption,
distribution, and metabolism. Relevant
data for use in risk assessment are available for key constituents.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again