Registration Dossier
Registration Dossier
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EC number: 938-793-9 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Worker: Vacuum Gas Oils, Hydrocracked Gas oils and Distillate fuel oils
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic |
Dermal |
(a) |
|
|
Inhalation |
4300 mg/m3/ 15 min (for lethality) [aerosol] |
1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats) |
Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences. |
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
||
Long-Term Exposure |
Systemic (b) |
Dermal |
2.9 mg/kg/8h |
30 mg/kg/day (NOAEL based on haematological parameters (decreased RBC, haemoglobin, HCT), clinical chemistry values (increased urea nitrogen and cholesterol) parameters and organ weight effects (increased liver weight, decreased thymus weight) in rats) |
Dose descriptor was modified to correct starting point of 69.8 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences. |
Inhalation |
68 mg aerosol /m3/8h [aerosol] |
125 mg/kg/day (NOEL based ondecreased body weight, decreased crown-rump length, decreased litter size and delayed ossification of some skeletal structuresin a rat developmental toxicity study with dermal dosing on GD 0-19) |
Dose descriptor was modified to correct starting point of 183.7 mg/m3/8 h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in workers. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences. |
||
Local |
Dermal |
(a) for 13-wk exposures and (c) for chronic exposures (dermal carcinogen) |
|
|
|
Inhalation |
(a) |
|
|
a) No hazard identified for this route (data available)
b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.
c) No-threshold effect and/or no dose-response information available
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
General Population HC_Dist_Vacuum Gas Oils
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic |
Dermal |
(a) |
|
|
Inhalation |
2600 mg/m3/ 15 min (for lethality) [aerosol] |
1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats) |
Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences. |
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
||
Long-Term Exposure |
Systemic (b) |
Dermal |
1.3 mg/kg/24h |
30 mg/kg/day (NOAEL based on haematological parameters (decreased RBC, haemoglobin, HCT), clinical chemistry values (increased urea nitrogen and cholesterol) parameters and organ weight effects (increased liver weight, decreased thymus weight) in rats) |
Dose descriptor was modified to correct starting point of 69.8 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences. |
Inhalation |
20 mg aerosol /m3/24h [aerosol] |
125 mg/kg/day (NOEL based ondecreased body weight, decreased crown-rump length, decreased litter size and delayed ossification of some skeletal structuresin a rat developmental toxicity study with dermal dosing on GD 0-19) |
Dose descriptor was modified to correct starting point of 144 mg/m3/24h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in general population. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences. |
||
Local |
Dermal |
(a) for 13-wk exposures and (c) for chronic exposures (dermal carcinogen) |
|
|
|
Inhalation |
(a) |
|
|
a) No hazard identified for this route (data available)
b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.
c) No-threshold effect and/or no dose-response information available
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