Registration Dossier
Registration Dossier
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EC number: 237-301-3 | CAS number: 13732-62-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No studies are available for Morpholinium toluene-4-sulphonate.
But data are available for the surrogates 4-toluene-sulphonic acid and morpholine.
The sensitizing potential of Morpholine was tested on 10 guinea pigs by Buehler's method (Wang & Suskind, 1988). Induction was performed with 5 % of Morpholine and during challenge, animals received concetrations of 0.1, 0.5 and 2 %. Morpholine showed no skin sensitizing properties.
In addition, two studies were performed with 4-toluene-sulphonic acid. In the first study, a guinea pig maximization test was performed under GLP (Habrinol Decin.s.r.o., 1988). The challenge exposure was done with 10% test substance in saline solution. The post-challenge evaluation was done at 48 hr and 72 hr. None of the tested animals showed positive responses. A further guinea pig sensitization study was performed according to OECD 406 under GLP (Hoechst, 1988). Challenge was done with 10 % of 4 -toluene-sulphonic acid and evaluation was done after 48 and 72 hours. 4 -toluene-sulphonic acid can be considered a non-sensitizer in guinea pigs as none of the test animals showed a positive response.
Migrated from Short description of key information:
The salt Morpholinium toluene-4-sulphonate is considered highly unlikely to possess skin sensitisation potential. None of the ions/salts that result from its dissociation in aqueous systems displayed skin sensitising properties in reliable standard tests. These surrogate substances were 4-toluene-sulphonic acid and morpholine.
Justification for selection of skin sensitisation endpoint:
A weight-of-evidence approach is used to assess the skin sensitisation hazard of Morpholinium toluene-4-sulphonate.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Based on the current weight-of-evidence, Morpholinium toluene-4-sulphonate is not subject to classification for skin sensitisation according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (GHS/CLP).
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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