Morpholinium toluene-4-sulphonate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable non-GLP study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Principles of method if other than guideline:

The test demonstrated the toxicity of an atmosphere saturated with vapours of the volatile components of the test item at 20 °C.
Reference:
according to H.F. Smith und C.P. Cargenter: J.Ind. Hyg.Tox. 26, 269 (1944).

GLP compliance:

no

Test type:

other: inhalation hazard test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Morpholinium toluene-4-sulphonate

EC Number:

237-301-3

EC Name:

Morpholinium toluene-4-sulphonate

Cas Number:

13732-62-2

Molecular formula:

C7H8O3S.C4H9NO

IUPAC Name:

morpholin-4-ium 4-methylbenzenesulfonate

Details on test material:

Name of the test substance used in the study report: Haerter 527 fluessig (approx. 75% aqueous solution)

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

Mean body weight: male: 198 g; female 173 g

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Rate of air: 200 L/hour
- System of generating a saturated vapour atmosphere: air was bubbled through a substance column of about 5 cm above a fritted glass disk in a glass cylinder.
- Temperature in air chamber: 20 °C

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

5.84 mg/l (saturated atmosphere)

No. of animals per sex per dose:

3

Control animals:

other: air control

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: group-wise documentation of clinical signs was performed; body weight of groups was determined before the start of the study and at the end of the observation period in surviving animals.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: slight irritation of the respiratory tract

Effect level:

ca. 5.84 mg/L air

Based on:

test mat.

Exp. duration:

8 h

Mortality:

none

Clinical signs:

other: slight mucosal irritation

Body weight:

no changes in body weight gain occurred compared to the controls

Gross pathology:

No abnormal changes could be detected.