Registration Dossier
Registration Dossier
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EC number: 237-301-3 | CAS number: 13732-62-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standard. The study was conducted before the OECD guideline 401 was first adopted.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Morpholinium toluene-4-sulphonate
- EC Number:
- 237-301-3
- EC Name:
- Morpholinium toluene-4-sulphonate
- Cas Number:
- 13732-62-2
- Molecular formula:
- C7H8O3S.C4H9NO
- IUPAC Name:
- morpholin-4-ium 4-methylbenzenesulfonate
- Test material form:
- other: aqueous solution
- Details on test material:
- Name of the test substance used in the study report: Haerter 527 fluessig; Morpholinium-o/p-toluolsuIfonat (approx. 75 % aqueous solution)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weights: males 195 g, females 170 g
The animals were offered a standardized animal laboratory diet.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test concentrations used were 68.1 % and 100% (v/v); aqueous solution.
- Doses:
- 6810 and 10000 ul/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 10 000 other: µl/kg
- Based on:
- test mat.
- Mortality:
- 6810 ul/kg: no deaths after 14 days
10000 ul/kg: 1/10 animals died (after 24 hours) - Clinical signs:
- other: dyspnea, apathy, staggering, tonic-clonic convulsions, diarrhea, urine intense yellow, poor general state
- Gross pathology:
- heart: acute dilatation, acute congestive hyperemia; intestine: atonic, diarrheic content
Any other information on results incl. tables
In the report, it was stated that a 75 % aqeous solution was tested so that an approximated value of 7500 mg/kg can be assumed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
