Registration Dossier
Registration Dossier
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EC number: 237-301-3 | CAS number: 13732-62-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Acutely harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
The test substance is soluble in water and dissociates to morpholinium and toluene-4-sulphonate ions. Since no studies on the short-term toxicity to aquatic invertebrates of the test substance are available, the assessment has been performed with the substance's dissociation products.
The toxicity of morpholine has been assessed in a guideline study according to OECD 202 with Daphnia magna as test species [NITE 2008]. At test termination after 48 h an EC50 of 45 mg/L could be determined.
For the assessment of aromatic sulphonic acids there are three short-term acute studies available which all use Daphnia magna as test organism. The key study is a GLP compliant guideline study conducted according to OECD 202 with the read-across substance benzenesulfonic acid [p-TA Coalition 2005]. Neither mortality nor immobility was observed at 100 mg/L (nominal). Thus, the 48 hour EC50 for is reported as >100 mg/L.Supporting studies have been conducted with benzenesulphonic acid [Huntsman 1995] as well as with toluene-4 -sulphonic acid [Aromatic Sulphonic Acids Consortium 1983] which both resulted in EC50 values > 100 mg/L (nominal).
Thus, taking all available information on the dissociation products into account it must be concluded that the test substance is acutely harmful to aquatic invertebrates.
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