Morpholinium toluene-4-sulphonate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: basic information given

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Principles of method if other than guideline:

Before OECD Guideline 404 was first adopted in 1981, skin irritation was tested using a BASF test.
The methods were based on Draize (Federal Register 38, No. 187, § 1500.41, p. 27019 (1973-09-27)).

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Morpholinium toluene-4-sulphonate

EC Number:

237-301-3

EC Name:

Morpholinium toluene-4-sulphonate

Cas Number:

13732-62-2

Molecular formula:

C7H8O3S.C4H9NO

IUPAC Name:

morpholin-4-ium 4-methylbenzenesulfonate

Details on test material:

Name of the test substance used in the study report: Haerter 527 fluessig (approx. 75% aqueous solution)
- Physical state:liquid

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

A standardized animal laboratory diet was used.

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin of the same animal

Amount / concentration applied:

1 ml of undiluted test substance

Duration of treatment / exposure:

1 min, 5 min, 15 min, 20 h

Observation period:

8 d

Number of animals:

2

Details on study design:

After application, the test substance was washed off with Lutrol.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 1 min

Score:

0.5

Max. score:

4

Reversibility:

fully reversible within: 8 d

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 1 min

Score:

0

Max. score:

4

Results 3

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 5 min

Score:

0.5

Max. score:

4

Reversibility:

fully reversible within: 8 d

Results 4

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 5 min

Score:

0

Max. score:

4

Results 5

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 15 min

Score:

0.5

Max. score:

4

Reversibility:

fully reversible within: 8 d

Results 6

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 15 min

Score:

0

Max. score:

4

Results 7

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 20 hours

Score:

2

Max. score:

4

Reversibility:

fully reversible within: 8 d

Results 8

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 20 hours

Score:

2

Max. score:

4

Reversibility:

fully reversible within: 8 d

Any other information on results incl. tables

Single animal data

 

Treatment	Animal	Measured time point: 24 hours
		Erythema	Edema	Additional findings
1 min	1	1	0	Reversible within 8 days
	2	0	0	Reversible within 8 days
5 min	1	1	0	Reversible within 8 days
	2	0	0	Reversible within 8 days
15 min	1	1	0	Reversible within 8 days
	2	0	0	Reversible within 8 days
20 h	1	2	2	Reversible within 8 days
	2	2	2	Reversible within 8 days

 

1 = no clear findings

2 = slight findings

3 = strong findings

4 = very strong findings