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EC number: 276-911-4
CAS number: 72829-25-5
FAT 40034/B was tested for mutagenic effects
on histidine-auxotrophic mutants of Salmonella typhimurium which
included TA 98, TA 100, TA 1535, TA 15 37 and TA 1538. The
investigations were performed with the following concentrations of the
trial substance with and without microsomal activation: 15, 45, 135, 405
and 1215 µg/0.1
ml. A repetition of the experiments was performed with the
concentrations of 25, 75, 225, 675 and 2025 µg/0.1
ml. In these experiments tests on Strain TA 1538 were included. In the
experiments performed with and without microsomal activation, comparison
of the number of back-mutant colonies in the controls and the cultures
treated with the various concentrations of FAT 40034/B revealed no
marked deviations. Based on the findings of the study, no evidence of
the induction of point mutations by FAT 40034/B or by the metabolites of
the substance formed as a result of microsomal activation was detectable
in the strains of S. typhimurium used in these experiments. Hence, FAT
40034/B was determined to be non-mutagenic in the bacterial reverse
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