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EC number: 276-911-4
CAS number: 72829-25-5
A study was performed to determine the
inhalation toxicity of FAT 40034/B in Tif: RAIF (SPF) rats. 10 males and
10 females were exposed to the test concentration of 1552 mg/m³ for
4 h in a nose-only exposure system. The concentration and the particle
size distribution of the dust in the vicinity of the animals was
monitored at 1 h intervals throughout the dust exposure. The size
distribution of the dust particles was measured with a Cascade Impactor
with selectron filters of 25 mm diameter and with a pore size of 0.2 µm.
During the 4-h exposure period and the subsequent 14 observation days,
no toxic symptoms were observed. No substance related gross organ
changes were recorded at the necropsy. No mortality was seen during the
study. Based on the findings of the study, the LC50 of a 4 h
dust exposure for rats of both sexes is greater than 1500 mg/m³
air, when evaluated for a 14 day post treatment observation period.
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