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EC number: 276-911-4 | CAS number: 72829-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- Refer chapter 13 for the detailed analogue justification.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer chapter 13 for the detailed analogue justification.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 500 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the read across data generated from the acute inhalation toxicity of Reactive Red 024, the LC50 of target substance (Reactive Red 024:1) is also considered to >1500 mg/m³ air.
- Executive summary:
Data on acute inhalation toxicity test was not available for the target substance (Reactive Red 024:1). To fill the data gaps, read across approach is adapted using similar substance Reactive Red 024. A study was performed to determine the inhalation toxicity of FAT 40034/B in Tif: RAIF (SPF) rats. 10 males and 10 females were exposed to the test concentration of 1552 mg/m³ for 4 h in a nose-only exposure system. The concentration and the particle size distribution of the dust in the vicinity of the animals was monitored at 1 h intervals throughout the dust exposure. The size distribution of the dust particles was measured with a Cascade Impactor with selectron filters of 25 mm diameter and with a pore size of 0.2 µm. During the 4-h exposure period and the subsequent 14 observation days, no toxic symptoms were observed. No substance related gross organ changes were recorded at the necropsy. No mortality was seen during the study. Based on the read across data generated from the acute inhalation toxicity of Reactive Red 024, the LC50 of target substance (Reactive Red 024:1) is also considered to >1500 mg/m³ air.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- Trisodium 5-[[4-chloro-6-(methylphenylamino)-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(2-sulphonatophenyl)azo]naphthalene-2,7-disulphonate
- EC Number:
- 274-417-3
- EC Name:
- Trisodium 5-[[4-chloro-6-(methylphenylamino)-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(2-sulphonatophenyl)azo]naphthalene-2,7-disulphonate
- Cas Number:
- 70210-20-7
- Molecular formula:
- C26H20ClN7O10S3.3Na
- IUPAC Name:
- trisodium 5-({4-chloro-6-[methyl(phenyl)amino]-1,3,5-triazin-2-yl}amino)-4-hydroxy-3-[(2-sulfonatophenyl)diazenyl]naphthalene-2,7-disulfonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- FAT 40034/B
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAIf (SPF) strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: raised on premises
- Weight at study initiation: 170 to 195 g
- Housing: 10 animals in Macrolon cages, type 4
- Diet: NAFAG, Gossau SG ad libitum
- Water: ad libitum):
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1
- Humidity (%): 55 ± 5
- Photoperiod (hrs dark / hrs light): 10 h light
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Remark on MMAD/GSD:
- None
- Details on inhalation exposure:
- Testing procedures:
For inhalation the rats were kept on separate PVC tubes positioned radially around the exposure chamber such that snout and nostrils of the animals only were exposed to the dust. The exposure was started 15 minutes after onset of the dust production, when the dust had reached an even dispersal throughout the chamber. During the exposure period the relative humidity inside the chamber was 50 % RH. After a 4 hour inhalation the rats were returned to their cages. Physical condition and incidence of death were monitored throughout an observation period of 14 days. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Remarks on duration:
- None
- Concentrations:
- 1552 (+/- 272) mg/m³
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- Dust production:
The dust was generated by injecting the test material with the help of a "Grafix Exaktomat Injector" into an air stream which was discharged into the exposure chamber through a nozzle under a pressure of 2 atm. at a rate of 20 L/min. The concentration and the particle size distribution of the dust in the vicinity of the animals was monitored at 1 hour intervals throughout the dust exposure. The concentration was determined gravimetrically by sampling the test atmosphere through a selectron filter of 50 mm diameter and with a pore size of 0.2 um (Schleicher and Schuell, Feldbach, Switzerland) at an air flow rate of 10 L/min. The size distribution of the dust particles was measured with a Cascade Impactor with selectron filters of 25 mm diameter and with a pore size of 0.2 mm (Schleicher and Schuell) at an air flow rate of 17.5 L/min. - Statistics:
- None
Results and discussion
- Preliminary study:
- None
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 500 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality was observed
- Clinical signs:
- other: During the 4-h exposure period and the subsequent 14 observation days, no toxic symptoms were observed.
- Body weight:
- None
- Gross pathology:
- The animals were submitted at random to a necropsy at the end of the observation period. No substance related gross organ changes were seen.
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The 4 h LC50 of FAT 40034/B with dust exposure for rats of both sexes is greater than 1500 mg/m³ air.
- Executive summary:
A study was performed to determine the inhalation toxicity of FAT 40034/B in Tif: RAIF (SPF) rats. 10 males and 10 females were exposed to the test concentration of 1552 mg/m³ for 4 h in a nose-only exposure system. The concentration and the particle size distribution of the dust in the vicinity of the animals was monitored at 1 h intervals throughout the dust exposure. The size distribution of the dust particles was measured with a Cascade Impactor with selectron filters of 25 mm diameter and with a pore size of 0.2 µm. During the 4-h exposure period and the subsequent 14 observation days, no toxic symptoms were observed. No substance related gross organ changes were recorded at the necropsy. No mortality was seen during the study. Based on the findings of the study, the LC50 of a 4 h dust exposure for rats of both sexes is greater than 1500 mg/m³ air, when evaluated for a 14 day post treatment observation period.
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