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EC number: 276-911-4
CAS number: 72829-25-5
of the Eye Reactions: Individual animal score
Observation time (Hr)
Degree of intensity
Area of cornea involved
A study performed to determine the eye
irritation potential of FAT 40034/A in New Zealand White rabbits in
accordance with the procedure set out in the "Hazardous Substances
Regulations" under the U.S.A. Federal Hazardous Substances Labelling Act
Sect. 191.12 (February 1965), with slight modification. The test
substance was instilled in the eyes of 3 male and 3 female rabbits and
observations for irritation were recorded at the time points of 1 h, 6
h, 1 day, 2 days, 3 days, 6 days and 10 days. One hour after application
of the test compound there was slight opacity and ulceration of the
cornea in 3/6 animals (unwashed eyes) and a conjunctival reaction in
6/6. The corneal changes had healed by day 3 and the conjunctivae were
normal, apart from slight injection of vessels in one animal, by day 6.
Staining of the cornea was visible up to 48 h. Based on the study
results, FAT 40034/A is considered to be a non-irritant to the eyes.
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