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EC number: 276-911-4
CAS number: 72829-25-5
guinea pig maximisation test was performed to determine the
sensitization potential of FAT 40034/E according to the OECD Guideline
Induction: Three pairs of intradermal injections (0.1 ml per
injection in physiological saline with 5 % concentration) were made
simultaneously into the left and right side of the shaved neck of the
test and control group animals.
Induction: In the test group FAT 40034/E was incorporated in
physiological saline and applied on a filter-paper patch to the neck of
the animals (patch 2x4 cm; approx. 0.4 g per patch; occluded
administration for 48 h). The control group was treated with the vehicle
only. Test Concentration was 50 % FAT 40034/E in physiological saline
Challenge: The test and control group animals were tested on one
flank with the dyed textile patch moistened with distilled water, (patch
2x2 cm; approx. 0.2 g per patch; occluded administration
for 24 h). The dyed textile patch moistened with distilled water.
the challenge, 10 % of the
animals of the test group showed skin reactions 24 and 48 h after
removing the dressings. Based on the study results FAT 40034/E does not
meet the criteria for classification according to CLP (1272/2008)
Regulation and is not considered as a sensitiser to rabbit skin.
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