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EC number: 276-911-4
CAS number: 72829-25-5
Based on experimental data FAT 40034
can be concluded to be not-biodegradable and stable in the environment.
The substance is designed to be used as a dye for diverse textile
fabrics. To ensure high performance and quality of the treated fabric,
these class of chemicals are designed to be not biodegradable by
microorganisms. The substance to be considered as not biodegradable,
hydrolytically stable in the pH range 4- 9, and not sensitive to
photodegradation. Hence, its concluded that the substance may be
Persistent (P) or Very Persistent (vP).
FAT 40034 has a very low Partition
coefficient value (-3.52). Due to very low partition coefficient value
conducting adsorption and desorption test was considered scientifically
not necessary. For the purpose of risk assessment Koc was calculated
using EPA tool KOCWIN and value of log Koc -0.613 is considered for
assessment. According to the screening criteria for bioaccumulation (B
for bioaccumulative, vB for very bioaccumulative) given in the technical
guidance provided by ECHA (ECHA 2008, Guidance on information
requirements and chemical safety assessment, Chapter R.11), a substance
does not fulfil the B and the vB criterion if its log Kow ≤4.5. The
octanol-water partition coefficient for the test item is log Pow =
-3.52. This value is below the threshold value of log Kow ≤4.5. Hence,
the substance is regarded as not bioaccumulative neither fulfilling the
B nor the vB criterion.
The substance is not harmful or toxic
upon oral ingestion as demonstrated by acute oral tests. Also no acute
systemic toxicity was observed when the substance was applied to the
skin or the mucosa of animals for tests on skin and eye irritation and
There is no evidence of chronic
toxicity from the available oral dose toxicity study is in rats. The
acute oral LD50 of FAT 40147 in rats of both sexes observed over a
period of 14 days is greater than 2000 mg/kg bw. Based on the results
obtained in the 28-day repeated toxicity study (Read across substance
FAT 40850) by gavage, the NOAEL was determined to be 300 mg/kg bw. The
substance is not classified as carcinogenic, mutagenic or reprotoxic
according to Regulation EC 1271/2008. No long-term studies for marine or
freshwater organisms are available. Therefore, based on current
knowledge, the substance does not fulfill the T criterion based on the
PBT criteria according to Annex XIII of the REACH Regulation. According
to the screening criteria provided by ECHA (ECHA 2008, Guidance on
information requirements and chemical safety assessment, Chapter R.11),
a substance has to be considered to fulfill the criteria for toxicity (T
for toxicity) if the EC50 or LC50 of a short-term aquatic toxicity test
is below 0.1 mg/L. The substance was tested for all three trophic levels
in the aquatic environment (fish, invertebrate and aquatic plants) using
acute test design and the lowest effect concentration is found to be LC/
EC50 >100 mg/L. Hence, it
can be concluded that the substance does not fulfil the criteria as a
Based on the above discussion, it is clear
that FAT 40034 (Reactive Red 024:1) is neither PBT nor vPvB.
Water: the substance is mobile and has low
Kow and vapour pressure and high water solubility., via human (oral &
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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