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EC number: 276-911-4
CAS number: 72829-25-5
Individual Animal Score:
study was performed to determine the primary-irritation index, which
serves as a measure of the acute irritation, provoked by the compound,
FAT 40034, on the skin of the rabbits according to the "Hazardous
Substances Regulations" under the U.S. Federal Hazardous Substances
Labelling Act Sect. 191.11 (February 1965). 6
rabbits (3 males and 3 females), New Zealand White breed, were shaved on
the whole back and flanks two days before treatment with an electric
clipper. The shaven skin on the left side was slightly scarified
immediately before treatment. A gauze patch 2.5 x 2.5 cm was soaked with
the test substance and immediately applied to the prepared skin. The
patch was covered with a plastic film 5 x 5 cm, which was fixed to the
body with adhesive tape. 10 g of the test compound was mixed with
10 ml of water to make a solution of 15 ml. 0.75 ml of which was applied
to each test site on a 2.5 cm square gauze pad. The
gauze patches were removed 24 h after the application. The reaction of
the skin was appraised upon removal and 72 h after it. The
primary irritation index was calculated as 0.8. The
effects were observed to be completely reversible by the end of 72 h. Therefore,
FAT 40034/A is to be considered as a non-irritant to the skin of rabbits.
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