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EC number: 232-227-8
CAS number: 7790-86-5
The key study of Hefner (2014), in which Daphnia magna was exposed for 48 h to Ce(NO3)3, yielded a 48-h EC50 of 6.9 mg Ce/L. This value corresponds to 12 mg CeCl3/L.
Three studies were included in this dossier as containing relevant
information on this endpoint. However, two of these studies were
disregarded in the evaluation because the results were not in agreement
with those of the key study. This was most likely due to the fact that
test concentrations were not analytically verified and effect
concentrations were based on nominal concentrations. Therefore, toxicity
may have been substantially underestimated.
The first disregarded study was that of Bringmann and Kühn (1959),
reporting a 48-h EC50 of > 1000 mg Ce/L after exposing Daphnia magna for
48 h to CeCl3. Cerium concentrations were not analytically verified
during the test. The second disregarded study was that of Bazin (1995).
This study reported a 48-h EC50 of > 100 mg Ce(NO3)3/L (corresponding to
a value > 42.96 mg Ce/L). Cerium disappeared from solution, with
concentrations <= 3 mg Ce/L after 24 h of exposure. Data for
recalculation of the EC50 value based on measured concentrations was not
The third study (Hefner, 2014) was also a 48-h study with Daphnia magna
in which the read across substance Ce(NO3)3 was used as test item and
dissolved cerium concentrations were analytically monitored during the
test. The 48-h EC50 was calculated based on mean measured concentrations
and was 6.9 mg Ce/L (corresponding to 16 mg Ce(NO3)3/L or, when
re-calculated to CeCl3, 12 mg CeCl3/L). These results are considered as
the key values for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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