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EC number: 232-227-8
CAS number: 7790-86-5
Three studies were identified on the acute toxicity of cerium to aquatic
invertebrates. Two of them (Bazin, 1995; Bringman and Kühn, 1959), were
assigned a reliability score of 3. The key study from Hefner (2014),
which was performed using Ce(NO3)3, was assigned a reliability score of
2 because the results of this study are used for read across purposes in
this dossier. In this study Daphnia magna juveniles were exposed to
cerium under semi-static conditions according to OECD guideline 202. The
48-h EC50 was calculated based on mean measured concentrations and was
6.9 mg Ce/L (corresponding to 16 mg anhydrous Ce(NO3)3/L or 12 mg
CeCl3/L). Based on these results, CeCl3 is considered harmful to aquatic
Three algal growth inhibition studies are available. Two of them (Tai et
al., 2010; Bringman and Kühn, 1959) were assigned a reliability score of
3 and flagged as supporting studies.
Four studies were identified on the toxicity of cerium to
microorganisms. A reliability score of 1 was assigned to the study
performed by Eisner (2013). This study was considered as key study. The
study was performed according to OECD guideline 209 using CeCl3 as test
substance. The 3-h NOEC and EC50 for activated sludge
microorganisms were determined to be 91 and 436 mg Ce/L, respectively (corresponding
to 160 and 767 mg CeCl3/L).
In accordance with Column 2 of REACH Annex IX, long-term tests on
aquatic invertebrates and fish, listed under standard information
requirements 9.1.5 and 9.1.6 respectively, do not need to be conducted
because the chemical safety assessment concludes that the substance is
of no immediate concern to the environment. Further, the available acute
data are adequate for classification and labelling purposes, and
PBT/vPvB assessment is not applicable for inorganic substances. In
conclusion, no further testing is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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