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EC number: 232-227-8
CAS number: 7790-86-5
Acute toxicity: oralA K1 acute oral toxicity test was performed in male and female Sprague-Dawley rats according to a guideline similar to OECD Guideline 401 and according to the Code of Federal Regulations 16:1500.3 (Shapiro R, 1991). The LD50 was estimated to be 2800 mg/kg bw. This study was selected as key study.Acute toxicity: inhalationAn acute inhalation study does not need to be conducted as the substance is classified as corrosive to the skin. In addition the substance appears asa clump and is produced as a solution. Therefore formation of respirable suspended particulate matter is unlikely.Acute toxicity: dermalAn acute dermal study does not need to be conducted as the substance is classified as corrosive to the skin.
Acute toxicity: oral
Shapiro R (1991) investigated the acute oral toxicity via gavage
of a single oral dose of cerium trichloride (50% aqueous solution) in 5
Sprague-Dawley rats per sex per dose. The dose levels tested were 2500
and 3500 mg/kg. The animals were observed for 14 days. At 2500 mg/kg 30%
mortality occurred by day 2 and at 3500 mg/kg 90% mortality occurred by
day 3. Following test material administration at 2500 mg/kg all animals
appeared lethargic. Most had a hunched posture and two had ano-genital
staining. All surviving animals recovered from the above symptoms by day
6 and gained weight over the 14-day observation period. At 3500 mg/kg
all animals appeared lethargic and most had hunched posture; several had
ano-genital staining and diarrhea. Prior to death many were prostrated.
The survivor (female) recovered from these toxic signs by day 4. At 2500
mg/kg the three decedents, all females, lost bodyweight prior to death.
At 3500 mg/kg all decedents lost weight prior to death. The survivor
(female) gained weight over the 14-day observation period. At 2500 mg/kg
necropsy of the decedents revealed distention of the stomach with
reddish-white discoloration of the pyloric region, discoloration of the
intestines and dark-colored fluid in the bladder. At 3500 mg/kg necropsy
of the decedents revealed distention of the stomach with discoloration
of the pyloric region in most animals. Discoloration of the intestines
and dark-colored fluid in the bladder was also noted in most animals. The
acute oral, single dose LD50 calculated by Probit Analysis was 2800 mg
cerium trichloride per kilogram body weight. This study is
designated as key study.
In addition, a K2 limit test reported a LD100 value of 5000 mg/kg
bw (Shapiro, 1991). This study has been disregarded as the dose
administered was inappropriate and the study did not permit to conclude
about the toxicity of cerium chloride.
Acute toxicity: inhalation
An acute inhalation study does not need to be conducted as the substance
is classified as corrosive to the skin (according to REACH Annex VIII
section 8.5, column 2). In addition the substance appears as a clump and
is produced as a solution. Therefore formation of respirable suspended
particulate matter is unlikely.
Acute toxicity: dermal
An acute dermal study does not need to be conducted as the substance is
classified as corrosive to the skin (according to REACH Annex VIII
section 8.5, column 2).
Based on the results of the acute oral toxicity study and according to
the criteria of the DSD and CLP Regulation, cerium trichloride should
not be classified as an acute oral toxicant.
No data were available to decide on the classification for the
inhalation and dermal route. As the substance is classified as corrosive
to the skin, no acute test via a second route of exposure should be
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