Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

Based on the acute oral discriminating dose > 15000 mg/kg bw of 1,8-bis[(4-methylphenyl)amino]anthraquinone and the NOAELs of 1000 mg/kg bw in the Repeated Dose 28 Day Oral Toxicity Study in Rodents and the Combined Repeated Dose Toxicity Study and Reproductive/ Developmental Toxicity Screening Study with structural analogue substances, no hazard is identified for systemic toxicity.

1,8-bis[(4-methylphenyl)amino]anthraquinone is not irritating/corrosive to the skin and not irritating to the eyes and not skin sensitising. Therefore, for local effects no hazard is identified.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Route of original study:
Oral
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
Oral
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

Based on the acute oral discriminating dose > 15000 mg/kg bw of 1,8-bis[(4-methylphenyl)amino]anthraquinone and the NOAELs of 1000 mg/kg bw in the Repeated Dose 28 Day Oral Toxicity Study in Rodents and the Combined Repeated Dose Toxicity Study and Reproductive/ Developmental Toxicity Screening Study with structural analogue substances, no hazard is identified for systemic toxicity.

1,8-bis[(4-methylphenyl)amino]anthraquinone is not irritating/corrosive to the skin and not irritating to the eyes and not skin sensitising. Therefore, for local effects no hazard is identified.