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EC number: - | CAS number: -
Ames tests on both components AMP and PTSA are negative with and without metabolic activation. AMP is tested negative for mutagenicity in mammalian cells. PTSA did not induce any chromosome aberrations.
Precipitation concentration was >5000 micrograms per plate
Mitotic Index: Concentration related plating efficiency was established in 1000 cells from each of two slides per test group. No influence on mitotic index was observed.
The precipitation concentration was > 1902 ug/mL
The number of micronucleated polychromatic erythrocytes per 2000 polychromatic erythrocytes in test article-treated groups was not statistically increased relative to their respective vehicle control in either male of female mice, regardless of dose level (maximum dose 60 mg/kg bw AMP) or bone marrow collection time.
No in vivo data are available for PTSA.
Based on the above information on the components, the substance is not to be classified for mutagenicity according to CLP (Regulation EC No 1272/2008).
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