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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1978
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPP 81-3 (Acute inhalation toxicity)
Version / remarks:
Acute Inhalation Study. FHSLA, CFR, Title 21, para. 191.10
Deviations:
yes
Principles of method if other than guideline:
the main deviation is the exposure duration of 1 h. In addition no information on body weight gain is provided.
GLP compliance:
no
Test type:
traditional method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
43% in water/(iso)propanol

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: No data
- Weight at study initiation: Males 255-280 g; females 237-261 9
- Fasting period before study: NA
- Housing: no data
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS: no data

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
air
Remark on MMAD/GSD:
no data
Details on inhalation exposure:
exposure to vaporized substance
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
1 h
Remarks on duration:
deviation from the guideline
Concentrations:
22 mg/L
No. of animals per sex per dose:
5 males and 5 females
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
Statistics:
NA

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 22 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
1 h
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 9.5 mg/L air
Based on:
act. ingr.
Exp. duration:
1 h
Remarks on result:
other: corrected for purity based on a density of 1 mg/cm3
Mortality:
1 male died on day 6
Clinical signs:
other: none reported
Body weight:
no data on body weight gain
Gross pathology:
pulmonary congestion in animal that died

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
No definite conclusion can be drawn.
Executive summary:

Five rats/sex were exposed to the substance during 1 hour at 22 mg/L(nominal). One animal died, showing pulmonary congestion. No toxic effects were seen in the other animals. The LC50 is > 9.5 mg/L (corrected for purity).