Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 December 2015 to 08 March 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study under GLP
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
other: UPLC-MS
Key result
Type:
log Pow
Partition coefficient:
-2.9
Temp.:
20 °C
pH:
7.1

Ratio
n-octanol : water
[v:v]

Analysed concentration

Pow

log Pow

pH

n-octanol
[g/L]

water
[g/L]

individual

mean

 

 

 

 

 

 

 

1:1

0.000901

0.668

1.3´10-3

1.2´10-3

-2.9

7.1

 

0.000761

0.671

1.1´10-3

 

-2.9

7.1

 

 

 

 

 

 

 

1:2

0.000651

0.488

1.3´10-3

1.2´10-3

-2.9

7.1

 

0.000501

0.469

1.1´10-3

 

-3.0

7.1

 

 

 

 

 

 

 

2:1

0.00121

0.922

1.3´10-3

1.3´10-3

-2.9

7.1

 

0.00131

0.945

1.3´10-3

 

-2.9

7.1

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Mean

1.3´10-3

 

-2.9

 

Standard deviation

1.2´10-4

 

 

 

 

 

 

 

 

 

 

1             Estimated value, calculated by extrapolation of the calibration curve.

Conclusions:
The logPow of the substance is -2.9
Executive summary:

In a shake flask method he octanol-water partition coefficient was determined to be -2.9 (as logPow) at pH 7.

Description of key information

In a shake flask method he octanol-water partition coefficient was determined to be -2.9 (as logPow) at pH 7.

For risk assessment the logKow is set at -1 (minimum value in EUSES)

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.9
at the temperature of:
20 °C

Additional information